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. 2021 Nov 25;12:777931. doi: 10.3389/fgene.2021.777931

FIGURE 1.

FIGURE 1

Immune landscape in the TCGA cohort. (A) The immune landscape of 22 ICIs in HCC patients; (B) Unsupervised clustering of tumor-infiltrating immune cells in the TCGA cohort, where rows represent tumor-infiltrating immune cells and columns represent samples; (C) Kaplan-Meier curves for overall survival (OS) of patients with different ICI clusters, where log-rank p = 0.018; (D) Proportion of tumor-infiltrating immune cells in the three ICI clusters, where Kruskal-Wallis was used to test and compare the statistical differences of the three ICI clusters. *p < 0.05; ∗∗p < 0.01; ∗∗∗p < 0.001; ∗∗∗∗p < 0.0001; (E) Cell interactions of tumor-infiltrating immune cell types. (F–H) Expression differences in PD-L1 (F), PD1 (G), and CTLA4 (H) between different ICI clusters (Kruskal-Wallis test, p < 0.0001).