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. 2021 Nov 25;12:777931. doi: 10.3389/fgene.2021.777931

FIGURE 2.

FIGURE 2

Identification of Immune-Related Gene Subtypes. (A) Unsupervised clustering of common DEGs in the three ICI subgroups, dividing patients into four groups; (B) Number of DEGs among subgroups as shown by Venn diagram; (C) Kaplan-Meier curves for the three subgroups of patients, where the log-rank test shows an overall p = 0.02; (D,E) Gene ontology (GO) enrichment analysis of ICI-associated signature genes: ICI signature genes A (D) and B (E), where x-axis indicates the number of genes in each GO term; (F) Proportion of tumor-infiltrating immune cells in the three gene clusters, where Kruskal-Wallis was used to test and compare the statistical differences of the three ICI clusters. *p < 0.05; ∗∗p < 0.01; ∗∗∗p < 0.001; ∗∗∗∗p < 0.0001; (G–I) Expression differences of PD-L1 (G), PD1 (H) and CTLA4 (I) using Kruskal-Wallis test.