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. 2021 Dec 3;22(23):13085. doi: 10.3390/ijms222313085

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Mouse PET/CT imaging of SV2A with ¹⁸F-SynVesT-1. (A) Representative axial images in SV2A⁺ NCI-H660 tumor at five different time points and NCI-H660 tumor blocked with ¹⁹F-SynVesT-1. Tumors indicated by yellow circles. (B) Time-activity curves (TAC) of ¹⁸F-SynVesT-1 in NCI-H660 tumors and muscle. (C) TAC of ¹⁸F-SynVesT-1 in the liver, brain, bladder, and kidney. (D) Comparative uptake of ¹⁸F-SynVesT-1 and ¹⁸F-SynVesT-1 with co-injection of ¹⁹F-SynVesT-1 in tissues of interest from the imaging studies in NCI-H660. For clarity, only the data at 50–60 min is presented. * p = 0.025; ** p = 0.0082. The data are presented as mean ± SD, n = 3.