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. 2021 Dec 1;22(23):13021. doi: 10.3390/ijms222313021

Figure 1.

Figure 1

Stau2 RNA duplexes are enriched in dendritically localized transcripts with extended 3′-untranslated region (UTR). (A) Schematic overview of hiCLIP (RNA hybrid and individual-nucleotide resolution ultraviolet crosslinking and immunoprecipitation) in brain. (B) Volcano plot showing differential enrichment of Stau2 bound mRNA transcripts from postnatal rat brains (P35), comparing Stau2-immunoprecipitation (IP) with input. The previously identified Stau2 target, Rgs4, known to localize in dendrites, is highlighted in red. Examples of additional Stau2 targets are highlighted in blue: Calm3, CamK2a, Mapt, Map2 and RhoA. (C) Venn diagram displaying the overlap between Stau2-IP mRNA targets from embryonic brain [19] and the newly identified Stau2-hiCLIP targets obtained from postnatal brains (P35). (D) Venn diagram displaying the overlap between Stau2 mRNA targets at P35, Stau2 up- and downregulated targets from embryonic brain [19] and neuropil-enriched mRNAs derived from hippocampal CA1 region [27].