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. 2021 Nov 30;22(23):13006. doi: 10.3390/ijms222313006

Figure 7.

Figure 7

Pharmacological inhibition of the STAT3 signaling pathway abrogates the chemotactic response to TGF-β. (A) U87 glioblastoma cell chemotaxis was assessed in the presence of 10 nM TGF-β, in the presence or not of 30 μM EGCG (left panel, vehicle ethanol), or tofacitinib, AG490 (right panel, vehicle DMSO). (B) Cells were treated for 30 min with 10 nM TGF-β or 30 μM ConA, and cell protein lysates were harvested to monitor Smad2, Smad3, and STAT3 phosphorylated status. (C) Cells were treated for 5 min with 30 μM ConA, and cell protein lysates were harvested to monitor Src phosphorylated status.