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. 2021 Dec 3;22(23):13072. doi: 10.3390/ijms222313072

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Proteomic profiling of MSC CM revealed the presence of proteins involved in cytoprotection. (A) Venn diagram shows the unique and shared protein numbers identified in CM3D and CM2D. (B) Confirmation of selected proteomic data by Western blot analysis of CAPN1, CCN3, MIF, GDF15, TGFB and CD9. (C) Network analysis of protein–protein interactions within CM3D with functions associated with cancer, carbohydrate metabolism and cardiovascular disease performed using the IPA software. (D) Network analysis of protein–protein interactions within CM3D unique and shared proteins with functions associated with the cardiovascular system development and function, cellular movement and tissue development performed using the IPA software. CM2D, conditioned medium derived from 2D cultures; CM3D, conditioned medium derived from 3D cultures; IPA, Ingenuity Pathway Analysis.