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. 2021 Dec 3;22(23):13072. doi: 10.3390/ijms222313072

Figure 5.

Figure 5

Combinatory exposure of MCF10A cells to MSC CM increased the viability of non-tumor breast cells exposed to Dox. The MCF10A cells were incubated with 0–500 nM of Dox alone and in combination with both conditioned media, CM2D or CM3D, and evaluated by MTS reduction assay. Cell viability is expressed in percentage (mean ± SD, n = 3–6) to non-treated MCF10A (control). Grid line represents 100% cell viability (control). Statistical significance is expressed relative to Dox as * p < 0.05, ** p < 0.01, **** p < 0.0001 and to control of non-treated cells, i.e., 100% viability as #### p < 0.0001. CM2D, conditioned medium derived from 2D cultures; CM3D, conditioned medium derived from 3D cultures; Dox, doxorubicin.