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. 2021 Nov 24;22(23):12696. doi: 10.3390/ijms222312696
ACN acetonitrile
AOP adverse outcome pathway
CBZ carbamazepine
CYP cytochrome P450
DMSO dimethyl sulfoxide
E-CBZ carbamazepine-10,11-epoxide
ECVAM European Centre for the Validation of Alternative Methods
EDTA ethylenediaminetetraacetic acid
EMA European Medicines Agency
EMS embryo solution
H hours
Hpf hours post fertilization
H2O water
HPLC high-performance liquid chromatography
HPPH 5-(4-hydroxyphenyl)-5-phenylhydantoin
IS internal standard
L liters
LAMO lamotrigine
LC-MS liquid chromatography-mass spectrometry
LLOQ lower limit of quantification
mDarT metabolic Danio rerio test
Min minutes
mL millilitres
mZEDTA metabolic zebrafish embryo developmental toxicity assay
PHE phenytoin
µL microliters
Xg time gravity
% percentage