ACN |
acetonitrile |
AOP |
adverse outcome pathway |
CBZ |
carbamazepine |
CYP |
cytochrome P450 |
DMSO |
dimethyl sulfoxide |
E-CBZ |
carbamazepine-10,11-epoxide |
ECVAM |
European Centre for the Validation of Alternative Methods |
EDTA |
ethylenediaminetetraacetic acid |
EMA |
European Medicines Agency |
EMS |
embryo solution |
H |
hours |
Hpf |
hours post fertilization |
H2O |
water |
HPLC |
high-performance liquid chromatography |
HPPH |
5-(4-hydroxyphenyl)-5-phenylhydantoin |
IS |
internal standard |
L |
liters |
LAMO |
lamotrigine |
LC-MS |
liquid chromatography-mass spectrometry |
LLOQ |
lower limit of quantification |
mDarT |
metabolic Danio rerio test |
Min |
minutes |
mL |
millilitres |
mZEDTA |
metabolic zebrafish embryo developmental toxicity assay |
PHE |
phenytoin |
µL |
microliters |
Xg |
time gravity |
% |
percentage |