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. 2021 Nov 25;22(23):12759. doi: 10.3390/ijms222312759

Figure 3.

Figure 3

Volcano plots of differentially expressed genes through mEV RNA pairwise comparisons of the three species using DESeq2 for data analysis. The X-axis represents log2 fold change (log2 FC) of the pairwise comparison, while the Y-axis indicates significance of differential expression (False Discovery Rate - FDR). The gray dots indicate no significant (NS) changes in the gene expression (|log2 FC| < 2, FDR > 0.05), the green dots denote genes with |log2 FC| > 2 but not significant (FDR > 0.05), light blue dots indicate very small changes in gene expression (|log2 FC| < 2), while red dots represent significantly up- and down-regulated genes (|log2 FC| > 2, FDR < 0.05). Purple numbers indicate the significantly up-regulated genes in cow compared to the other reported species, the orange numbers indicate those up-regulated in donkey, and the teal numbers refer to goat over-expressed genes.