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Influence of HFD and proximal tubular Adam17 deletion on macrophage-mediated inflammation. (A) Cortical Tnf-α gene expression. (B) Cortical MCP-1 protein expression. (C) Number of glomerular F4/80 positive cells. Representative images of glomerular F4/80 immunostaining. 400× magnification, scale bar 20 μm. Data are expressed as mean ± SD. Abbreviations: SD, standard diet; HFD, high-fat diet; Adam17WT, wild type; Adam17KO, knockout. * p < 0.05 HFD vs. SD, $ p < 0.05 KO vs. WT.
