Figure 3.

Generation of Ca²⁺ signals in cortical astrocytes in neuroglial culture in response to the application of 0.5 μg/mL SeNPs in calcium-free medium containing 0.5 mM EGTA (A), after depletion of ER with thapsigargin (B, 10 μM), in the presence of ryanodine receptor antagonists dantrolene (C, 30 μM) and ryanodine (D, 100 μM) and IP₃R inhibitors 2-APB (E, 30 µM) and xestospongin C (F, XeC, 3 µM). Here, Ca²⁺ signals of astrocytes in one experiment are presented.