Figure 3.

The cellular permeability and toxicity of LPMP in HepG2 hepatocytes. (A) HepG2 cells were assayed by flow cytometry for fluorescence levels of FITC after various periods of treatment with LPMP-FITC (200 μg·mL⁻¹). (B) The effect of LPMP on the catalytic activity of PTP1B protein in HepG2 cells. The intracellular PTP1B protease activity was measured at different administration periods of 100 and 200 μg·mL⁻¹ LPMP. (C) Cytotoxicity of sodium palmitate on HepG2 cells in the absence or presence of 50, 100, 150, 200, and 300 μg·mL⁻¹ of PA for 24 h at 37 °C. (D) Cytotoxicity of LPMP on HepG2 cells in the absence or presence of 50, 100, 200, 300, 400, and 500 μg·mL⁻¹ of LPMP for 24 h at 37 °C. Data are presented as means ± SEM (n = 5). * p < 0.05, ** p < 0.01, *** p < 0.001 versus control group.