Concentrations of PLA1A in plasma and synovial fluids (SF) from arthritis patients and control donors. Concentrations of PLA1A in plasma and synovial fluids from RA patients and control groups were monitored using ELISA. (A) Human platelet-free plasma samples were collected from 12 healthy donors; 38 EA patients (B), including 19 males and 19 females); and 62 undergoing treatment SLE patients (C), including 9 males and 53 females. (D) Synovial fluid samples were collected from 3 PsoA patients, 5 RA patients, 3 OA patients, and 3 gout patients and were treated with 0.5 mg/mL hyaluronidase for 5 min at room temperature before measurement. For statistical comparative analyses, PLA1A concentrations in EA patient plasma were compared to that in healthy donors and in SLE patients. PLA1A concentrations in synovial fluid of RA patients were compared to that in PsoA, OA, and gout donors.