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. 2021 Nov 29;22(23):12931. doi: 10.3390/ijms222312931

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Metabolic profiling of candidate biomarkers and the main metabolic pathways implicated in the early stress stage. It is presented the metabolites with highest influence on the model (match in all the statistical methods, green dot), influence on metabolites (partial match in the statistical methods, yellow dot) and other metabolites presenting an impact on metabolism. The up- and downregulated metabolites are indicated with up and down arrows, respectively. Abbreviations: DG, diacylglycerol; ChoE, cholesterol ester; TMAO, trimethylamine N-oxide; TMA, trimethylamine; GABA, gamma aminobutyric acid.