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Prevalence of mice with positive IgA immune-fluorescence staining. In each mouse treated with P. gingivalis or saline (control) via nasal administration, IgA immune-fluorescence staining in glomeruli was observed under same condition. Each group consists of 10 mice. Numbers of mice with IgA immune-fluorescence staining treated with P. gingivalis were significantly higher than those of control mice at day 42 (p < 0.01), at day 42 and at day 56 (p < 0.01) after treatment of bacteria.
