Figure 2.

S100A9 regulates neutrophil recruitment. Mice were pre-treated with intraperitoneal injections of vehicle or ABR-238901 (10 mg/kg and 30 mg/kg) 1 h before CLP. (A) Lung MPO was determined 4 h after CLP. (B) Blood was collected 4 h after CLP and Mac-1 expression (MFI) on neutrophils was determined by flow cytometry. (C) Aggregate data on Mac-1 expression. Statistical comparisons were performed using non-parametrical tests (Kruskal–Wallis on ranks followed by Dunn’s multiple comparisons). Data are presented as box plots with median (25–75 percentile) and the whiskers extend from the minimum to the maximum levels and dots represent sample values. ^# p < 0.05 vs. Sham, and * p < 0.05 vs. Vehicle, n = 4.