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Functional domains of human SECISBP2 with the position of mutations described hitherto. Arrowheads denote the location of ATG codons; NLS: nuclear localisation signal (380–390); NES: nuclear export signals (634–657 and 756–770); SID: Sec incorporation domain; CRD: cysteine rich domain; RBD: minimal RNA-binding domain with the Lysine-rich domain (K-rich) and the L7Ae RNA-binding module; the black bar denotes the minimal protein region required for full functional activity in vitro.
