Figure 11.

Effects of GPR55 blockage on atherosclerotic plaque formation in vivo. (A) High fat-diet (HFD)-induced atherosclerosis protocol. Sixteen-week aged ApoE^−/− mice were followed up for 8 weeks under normal chow diet (ND) or were fed with an HFD from 16 weeks to 24 weeks (HFD). Another group of mice, that is, the HFD plus CID16020046 group, was intraperitoneally treated with 1 mg/kg CID16020046, five times per week during HFD feeding before euthanasia. (B) Images of H&E and oil red O staining in cross-sections of the aortic sinuses from the ND, HFD, or HFD plus CID16020046 groups. Representative images from five or six independent mice are shown. (C) Quantitative data are presented as the means ± SEM of five or six independent mice. ** p < 0.01 compared with an ND, ## p < 0.01 compared with an HFD.