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. 2021 Nov 28;14(23):7278. doi: 10.3390/ma14237278

Table 1.

Polymer micelles prepared for skin delivery described in the literature in the last decade.

Active
Compound		 Structure Polymers Used as Micellar
Carriers		 Conclusions Ref.
ANTI-AGEING
Oleanolic Acid graphic file with name materials-14-07278-i001.jpg Poloxamer 407 Enhanced wrinkle alleviation [39]
CoQ10 graphic file with name materials-14-07278-i002.jpg Oleyl-hyaluronan
Hexyl-hyaluronan		 Enhancement in skin hydration [40]
ACNE VULGARIS
All-trans Retinoic Acid (Tretinoin) graphic file with name materials-14-07278-i003.jpg Poly(ethylene glycol) conjugated phosphatidylethanolamine Higher stability with slower drug oxidation [20]
All-trans Retinoic Acid (Tretinoin) Diblock methoxy-poly(ethylene glycol)-poly(hexyl-substituted lactic acid) Higher efficiency than marketed formulations [41]
Adapalene graphic file with name materials-14-07278-i004.jpg D-α-tocopheryl polyethyleneglycol 1000 succinate Targeted drug delivery capacity
Higher efficiency at lower dose than marketed formulations		 [42]
Benzoyl peroxide graphic file with name materials-14-07278-i005.jpg Pluronic® F127 Targeted drug delivery capacity [43]
PSORIASIS
Tacrolimus graphic file with name materials-14-07278-i006.jpg Diblock methoxy-poly(ethylene glycol)-poly(hexyl-substituted lactic acid) Enhancement in skin drug deposition [21]
Resveratrol graphic file with name materials-14-07278-i007.jpg Pluronic® P123
Pluronic® F127		 Decrease in the cytokine levels [23]
Silibinin graphic file with name materials-14-07278-i008.jpg - Reduction of psoriasis index area [44]
FUNGAL INFECTIONS
Clotrimazole
Fluconazole		 Inline graphic Inline graphic Diblock Methoxy-poly(ethylene glycol)-poly(hexyl-substituted lactic acid) Enhancement in skin drug deposition [45]
Terconazole graphic file with name materials-14-07278-i011.jpg Pluronic® P123
Pluronic® F127
Cremophor EL		 Higher permeation
Higher skin deposition		 [46]
OTHER SKIN DISEASES AND CONDITIONS
Imiquimod graphic file with name materials-14-07278-i012.jpg Diblock methoxy-poly(ethylene glycol)-)-hexyl-substituted lactide Higher delivery efficiency at lower dose than the marketed formulation [47]
Spironolactone graphic file with name materials-14-07278-i013.jpg Diblock methoxy-poly(ethylene glycol)-poly(hexyl-substituted lactic acid) Targeted drug delivery capacity [48]