Table 5.
Ocular Data after Gender and Age Matching for Groups of Glaucomatous subjects and Control subjects.
| A vs. B N = 288:32 |
A vs. C N = 314:314 |
B vs. C N = 62:310 |
p-Value | ||||||
|---|---|---|---|---|---|---|---|---|---|
| a | b | c | |||||||
| OD/OS | 0.68 | 0.58 | 0.68 | ||||||
| OD | 151 (52.4%) | 18 (56.3%) | 160 (51.0%) | 153 (48.7%) | 30 (48.4%) | 159 (51.3%) | |||
| OS | 137 (47.6%) | 14 (43.7%) | 154 (49.0%) | 161 (51.3%) | 32 (51.6%) | 151 (48.7%) | |||
| VA (logMAR) | 0.1 ± 0.2 | 0.2 ± 0.6 | 0.1 ± 0.2 | 0.3 ± 0.5 | 0.3 ± 0.6 | 0.4 ± 0.7 | 0.37 | <0.001 | 0.20 |
| AL (mm) | 25.2 ± 1.8 | 25.6 ± 1.8 | 25.1 ± 1.8 | 25.7 ± 2.1 | 25.9 ± 1.9 | 25.6 ± 2.4 | 0.22 | <0.001 | 0.37 |
| <24 | 78 (27.1%) | 7 (21.9%) | 97 (30.9%) | 71 (22.8%) | 13 (21.0%) | 86 (27.8%) | |||
| 24–25.9 | 121 (42.0%) | 8 (25.0%) | 118 (37.6%) | 100 (32.0%) | 16 (25.8%) | 87 (28.2%) | |||
| 26 | 89 (30.9%) | 17 (53.1%) | 99 (31.5%) | 141 (45.2%) | 33 (53.2%) | 136 (44.0%) | |||
| IOP (mmHg) | 14.6 ± 3.4 | 14.9 ± 3.3 | 14.8 ± 3.6 | 14.8 ± 4.0 | 15.1 ± 4.0 | 14.7 ± 3.8 | 0.66 | 0.84 | 0.45 |
| CCT (µm) | 543.9 ± 35.9 | 542.2 ± 31.0 | 544.0 ± 35.4 | 536.4 ± 34.1 | 530.7 ± 44.7 | 536.5 ± 36.0 | 0.80 | 0.007 | 0.34 |
| VF | −1.4 ± 1.8 | −1.4 ± 1.5 | −1.2 ± 1.9 | −9.0 ± 8.6 | −1.0 ± 1.3 | −10.3 ± 9.0 | 0.98 | <0.001 | <0.001 |
| Macular VD (%) | |||||||||
| Superior | 50.1 ± 4.8 | 47.3 ± 5.1 | 49.9 ± 5.3 | 43.5 ± 7.1 | 46.4 ± 6.7 | 42.9 ± 7.5 | 0.002 | <0.001 | <0.001 |
| Center | 18.4 ± 6.8 | 18.0 ± 6.4 | 18.6 ± 6.3 | 16.1 ± 7.0 | 17.8 ± 6.2 | 16.0 ± 6.9 | 0.72 | <0.001 | 0.06 |
| Inferior | 49.5 ± 5.1 | 46.1 ± 4.8 | 49.4 ± 5.4 | 41.0 ± 7.7 | 45.7 ± 6.1 | 40.2 ± 8.0 | 0.001 | <0.001 | <0.001 |
| Peripapillary VD (%) | |||||||||
| Superior | 51.7 ± 5.2 | 47.1 ± 6.4 | 51.3 ± 5.3 | 39.1 ± 10.6 | 47.3 ± 5.9 | 37.9 ± 10.6 | <0.001 | <0.001 | <0.001 |
| Inferior | 52.7 ± 5.4 | 48.5 ± 5.2 | 52.4 ± 5.4 | 36.6 ± 10.2 | 47.4 ± 5.1 | 35.4 ± 10.3 | <0.001 | <0.001 | <0.001 |
| cpRNFL Thickness (µm) | |||||||||
| Superior | 101.0 ± 10.1 | 85.6 ± 10.2 | 100.8 ± 10.0 | 76.0 ± 16.0 | 86.6 ± 10.3 | 75.1 ± 15.4 | <0.001 | <0.001 | <0.001 |
| Inferior | 96.9 ± 9.4 | 85.1 ± 9.8 | 96.3 ± 8.9 | 69.3 ± 15.0 | 81.5 ± 10.7 | 67.8 ± 13.4 | <0.001 | <0.001 | <0.001 |
| GCC Thickness (µm) | |||||||||
| Superior | 96.0 ± 5.9 | 86.3 ± 7.4 | 95.8 ± 5.4 | 76.6 ± 12.2 | 85.9 ± 8.0 | 76.3 ± 13.0 | <0.001 | <0.001 | <0.001 |
| Inferior | 95.4 ± 5.9 | 83.5 ± 7.3 | 95.1 ± 5.6 | 70.5 ± 12.5 | 81.3 ± 8.1 | 70.0 ± 12.8 | <0.001 | <0.001 | <0.001 |
| C/D Ratio | 49.8 ± 19.5 | 66.5 ± 18.6 | 51.5 ± 19.4 | 80.7 ± 15.6 | 70.5 ± 14.8 | 82.5 ± 13.4 | <0.001 | <0.001 | <0.001 |
| Rim Area | 133.3 ± 37.2 | 109.3 ± 63.7 | 130.8 ± 37.1 | 72.0 ± 39.1 | 98.1 ± 50.8 | 69.8 ± 37.9 | 0.04 | <0.001 | <0.001 |
| Disc Area | 203.5 ± 48.4 | 218.9 ± 56.2 | 204.2 ± 49.4 | 212.6 ± 60.1 | 212.8 ± 48.8 | 216.4 ± 59.5 | 0.09 | 0.06 | 0.66 |
Group A, control eyes; Group B, pre-perimetric glaucoma eyes; Group C, glaucoma eyes; a p-value, A vs. B; b p-value, A vs. C; c p-value, B vs. C; Unit. VA (logMAR); VF (mean deviation); VD (%); thickness (µm); C/D ratio (%); Rim area (0.01 mm2); Disc area (0.01 mm2); Abbreviation. OD, right eye; OS, left eye; VA, visual acuity; AL, axial length; CCT, central corneal thickness; VF, visual field; VD, vessel density; cpRNFL, circumpapillary retinal nerve fiber layer; GCC, ganglion cell complex; C/D Ratio, cup to disc ratio.