Table 6.
One Way Analysis of OCTA parameters and OCT measurement among the glaucoma severity groups.
| Group 0 N = 540 |
Group 1 N = 67 |
Group 2 N = 224 |
Group 3 N = 103 |
Group 4 N = 194 |
p-Value | Tukey Test | |
|---|---|---|---|---|---|---|---|
| Age (years) | 44.4 ± 13.8 | 45.7 ± 12.7 | 48.3 ± 12.2 | 51.3 ± 12.8 | 56.1 ± 14.5 | <0.001 | 4 > 0, 1, 2, 3 |
| Axial Length (mm) | 25.2 ± 1.7 | 25.9 ± 1.8 | 25.9 ± 1.8 | 26.3 ± 2.8 | 25.1 ± 2.2 | <0.001 | 1, 2, 3 > 0, 4 |
| Gender | 0.463 | ||||||
| Male | 169 (31.3%) | 43 (64.2%) | 137 (61.2%) | 69 (67.7%) | 132 (68.0%) | ||
| Female | 371 (68.7%) | 24 (35.8%) | 87 (38.8%) | 33 (32.4%) | 62 (32.0%) | ||
| Macular VD (%) | |||||||
| Superior | 50.3 ± 4.8 | 46.6 ± 6.5 | 46.1 ± 6.0 | 41.2 ± 6.6 | 38.1 ± 7.5 | <0.001 | 0 > 1, 2 > 3 > 4 |
| Center | 18.4 ± 6.4 | 18.1 ± 6.1 | 17.0 ± 6.6 | 14.7 ± 6.1 | 14.5 ± 7.0 | <0.001 | 0 > 2; 0, 1 ,2 > 3, 4 |
| Inferior | 49.7 ± 5.0 | 46.0 ± 5.9 | 43.7 ± 6.8 | 38.0 ± 7.2 | 35.2 ± 7.7 | <0.001 | 0 > 1, 2 > 3 > 4 |
| Peripapillary VD (%) | |||||||
| Superior | 51.8 ± 4.9 | 47.4 ± 5.8 | 43.6 ± 8.4 | 37.1 ± 10.2 | 29.5 ± 9.2 | <0.001 | 0 > 1 > 2 > 3 > 4 |
| Inferior | 52.9 ± 5.2 | 47.6 ± 5.0 | 41.5 ± 8.1 | 33.2 ± 9.2 | 26.9 ± 7.8 | <0.001 | 0 > 1 > 2 > 3 > 4 |
| cpRNFL Thickness (µm) | |||||||
| Superior | 100.8 ± 9.7 | 86.8 ± 10.4 | 81.2 ± 13.5 | 74.0 ± 14.6 | 67.1 ± 14.9 | <0.001 | 0 > 1 > 2 > 3 > 4 |
| Inferior | 96.8 ± 9.0 | 82.0 ± 10.7 | 74.6 ± 12.8 | 65.2 ± 14.0 | 61.1 ± 13.4 | <0.001 | 0 > 1 > 2 > 3 > 4 |
| GCC Thickness (µm) | |||||||
| Superior | 95.9 ± 5.8 | 86.0 ± 7.8 | 81.1 ± 10.2 | 73.9 ± 12.6 | 69.4 ± 12.4 | <0.001 | 0 > 1 > 2 > 3 > 4 |
| Inferior | 95.3 ± 5.7 | 81.5 ± 8.0 | 75.0 ± 12.1 | 65.9 ± 10.4 | 64.2 ± 11.1 | <0.001 | 0 > 1 > 2 > 3 > 4 |
| Cup/Disc Ratio (%) | 49.7 ± 19.5 | 69.5 ± 16.0 | 77.5 ± 14.0 | 83.4 ± 13.7 | 89.5 ± 11.0 | <0.001 | 0 < 1 < 2 < 3 < 4 |
| Rim Area (0.01 mm2) | 133.3 ± 36.7 | 100.1 ± 50.2 | 78.5 ± 33.9 | 69.8 ± 38.2 | 51.6 ± 30.3 | <0.001 | 0 > 1 > 2, 3 > 4 |
| Disc Area (0.01 mm2) | 203.4 ± 48.6 | 213.9 ± 49.8 | 209.5 ± 51.8 | 221.0 ± 81.9 | 216.7 ± 60.6 | 0.006 |
Group 0, control eyes; Group 1, pre-perimetric glaucoma eyes; Group 2, early glaucoma eyes with −2 dB > VF(MD) ≥ −6 dB; Group 3, moderate glaucoma eyes with −6 dB > VF(MD) ≥ −12 dB; Group 4, late glaucoma eyes with VF(MD) < −12 dB; OD, right eye; OS, left eye; VA, visual acuity; AL, axial length; CCT, central corneal thickness; VF, visual field; VD, vessel density; cpRNFL, circumpapillary retinal nerve fiber layer; GCC, ganglion cell complex; MD, mean deviation.The OCTA-based VD and OCT-based structural thickness of the two groups (advanced, terminal stage) are shown in Table 7. No significant difference was noted between the two groups in terms of peripapillary and macular VDs, cpRNFL and GCC thickness, or CD ratio.