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. 2021 Dec 3;22(23):13088. doi: 10.3390/ijms222313088

Figure 3.

Figure 3

Comparison of three complementary biomarkers of Se-status in relation to SELENOP autoimmunity. The patients with positive SELENOP-aAb (BI > 5) displayed relatively high (A) total Se, while (B) SELENOP or (C) GPX3 activity were not different in comparison to SELENOP-aAb-negative patients. SELENOP-aAb correlated positively to (D) serum Se and (E) SELENOP, but not to (F) GPX3 activity. When applying a more stringent cut-off for positivity (BI > 10), serum samples with positive SELENOP-aAb displayed relatively high (A) total Se and (B) SELENOP, whereas (C) GPX3 activity was not elevated. Positive correlation was observed between SELENOP-aAb and (G) serum Se and (H) SELENOP. (I) GPX3 activity was inversely correlated to SELENOP-aAb. Comparisons between two groups were conducted by Mann–Whitney test. Correlations were tested by Pearson’s correlation analysis with two-tailed p-values. p-values < 0.05 were considered statistically significant; n.s. indicates p ≥ 0.05; * indicates p < 0.05, and ** indicates p < 0.01.