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. 2021 Dec 3;22(23):13111. doi: 10.3390/ijms222313111

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Longitudinal study of retinal thickness in a Grm6^Cre Rd1 mouse treated with human rod opsin. Total retinal thickness (A) and INL thickness (B) in rod opsin-treated and control mice within degenerate retinas (control n = 8, treated n = 7). Representative OCTs of retinae pre-treatment at 2 months old (C) and post-rod opsin treatment at 8 months old (D) from rd1/rd1. Longitudinal study of total retinal thickness (E) and INL thickness (F) in rod opsin-treated and control mice within non-degenerate rd1/+ retinas (control n = 8, treated n = 10). Representative OCTs of retinae pre-treatment at 2 months old (C) and post-rod opsin treatment at 8 months old (D) from rd1/rd1 and at 2 months old (G) and post-rod opsin treatment at 8 months old (H) in rd1/+. No significant difference was found between the control and treated groups in either group; however, time was shown to have a significant effect on INL thickness (p = 0.0037 (rd1/rd1), p < 0.0001 (rd1/+)) and total retinal thickness (p = 0.0175 (rd1/rd1), p = 0.0004 (rd1/+)) (two-way mixed ANOVA, repeated measures, Bonferonni multiple).