Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2021 Dec 3;22(23):13111. doi: 10.3390/ijms222313111

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

PMC Copyright notice

Toxicity study of opsin-treated Grm6^Cre rd1/rd1 retinae. (A) Longitudinal study and (B) non-longitudinal study of INL thickness in rod opsin; ReaChR- and CoChR-3M-treated and control mice. (C) mCherry relative expression in rod opsin; ReaChR- and CoChR-3M-treated and non-injected control mice. (D) PKCα relative expression and (E) IBA1/AIF1 relative expression in rod opsin; ReaChR- and CoChR-3M-treated and control mice. There was a significant decrease in the INL thickness observed over time in all mice (two-way RM-ANOVA main effect of time p < 0.001), but no impact of any of the treatments was found (p > 0.05). Analysis of the expression of PKCa and IBA1/AIF1 found no difference between any of the treatments compared to controls (the Kruskal–Wallis test with Dunn’s multiple comparisons correction, p > 0.05).