Table 1.
Baseline characteristics of the 117 patients on invasive mechanical ventilation according to their 90-day survival status.
| Total (N = 117) |
Survivors (N = 85) |
Non-Survivors (N = 32) |
p-Value | |
|---|---|---|---|---|
| Baseline characteristics | ||||
| Age | 63 (56–72) | 61 (54–67) | 71.5 (62.75–77) | <0.001 |
| Male | 88 (75.2) | 64 (75.3) | 24 (75.0) | 0.974 |
| ABO blood group | ||||
| A | 42 (35.9) | 32 (37.6) | 10 (31.2) | 0.605 |
| B | 17 (14.5) | 13 (15.3) | 4 (12.5) | 0.419 |
| O | 41 (35) | 30 (35.3) | 11 (34.4) | 0.366 |
| AB | 2 (1.7) | 1 (1.2) | 1 (3.1) | 0.218 |
| BMI > 25 kg·m2 | 73 (62.4) | 59 (69.4) | 14 (43.8) | 0.011 |
| Hypertension | 68 (58.1) | 48 (56.5) | 20 (62.5) | 0.556 |
| Diabetes | 24 (20.5) | 15 (17.6) | 9 (28.1) | 0.211 |
| Metabolic syndrome | 34 (29.1) | 29 (34.1) | 5 (15.6) | 0.05 |
| Chronic respiratory disease | 22 (18.8) | 15 (17.6) | 7 (21.9) | 0.602 |
| Chronic kidney disease | 11 (9.4) | 8 (9.4) | 3 (9.4) | 0.995 |
| Immunodeficiency | 24 (20.5) | 15 (17.6) | 9 (28.1) | 0.211 |
| Statins intake | 23 (19.7) | 12 (14.1) | 11 (34.4) | 0.014 |
| Systemic steroids intake | 9 (7.7) | 6 (7.1) | 3 (9.4) | 0.675 |
| Charlson index | 3 (2–4) | 2 (1–3) | 4 (2–6) | <0.001 |
| SAPS II score | 34 (27–40) | 30.5 (25–38.25) | 38 (35–45) | 0.02 |
| SOFA score | 5 (3–7) | 4 (3–7) | 5 (3–6) | 0.966 |
| Total lungs volume on CT (cm3) | 3257 (2447–4016) | 3142 (2285–3804) | 3742 (3275–4158) | 0.01 |
| Lesions/lungs ratio on CT (%) | ||||
| Ground glass/lungs ratio | 24.8 (12.6–34.4) | 26.9 (13.6–36.6) | 21.5 (7.1–28.2) | 0.862 |
| Condensations/lungs ratio | 5.1 (2.1–12.4) | 6.6 (3.1–16) | 2.1 (0.3–8.2) | 0.495 |
| All lesions/lungs ratio | 31.8 (15.6–46.6) | 34.1 (19.9–49.7) | 26.8 (9.2–36.3) | 0.034 |
| Days from symptoms onset to intubation |
9 (6–11.25) | 8.5 (6–11) | 9 (6–12) | 0.3 |
| Days from ICU admission to intubation |
0 (0–1) | 1 (0–1) | 0 (0–1) | 0.364 |
| Biology (worst value during first 48H after ICU admission) | ||||
| Lymphocyte count (×109/L) | 0.69 (0.5–0.95) | 0.7 (0.53–1) | 0.61 (0.44–0.78) | 0.382 |
| Neutrophil to Lymphocyte Ratio | 11.1 (8.3–15.5) | 10.6 (7.5–15.3) | 12.6 (10.5–19.8) | 0.005 |
| D-Dimers (mg/L) | 3.44 (1.64–5) | 3.34 (1.52–5) | 4 (1.84–5) | 0.9 |
| Fibrinogen (g/L) | 8.1 (6.9–9.4) | 8.1 (7.1–9.5) | 8 (6.9–9.4) | 0.995 |
| CRP (mg/L) | 201(126–302) | 179 (120–248) | 283 (162–324) | 0.29 |
| Creatinine (µmol/L) | 85 (67–138) | 84 (65–127) | 98 (78–153) | 0.048 |
| LDH (UI/L) | 447 (368–535) | 435 (347–491) | 539 (443–635) | 0.005 |
| Ferritin (ng/mL) | 1418 (968–2321) | 1175 (950–1778) | 2728 (2342–6049) | 0.021 |
| Invasive ventilation parameters during first 24 h | ||||
| PaO2/FiO2 | 130 (100–180) | 140 (100–180) | 120 (100–160) | 0.457 |
| PEEP (cmH2O) | 12 (10.3–14) | 12 (12–14) | 12 (10–15) | 0.483 |
| Plateau pressure (cm H2O) | 25 (21.7–28.3) | 23.5 (21.0–28.2) | 26.0 (23.6–28.8) | 0.353 |
| Respiratory compliance (mL/cmH2O) | 33 (28.2–45) | 40 (29–46) | 31 (27–40) | 0.018 |
| Mechanical power (J/min) | 15.6 (13.3–19.6) | 15.5 (13.5–19.1) | 15.9 (12–19.8) | 0.836 |
Results are expressed as n (%) or median (25th–75th percentile). Statistical significance in bold.