Table 4.
Dropouts and adverse events.
| Author (Year) | Drop-Outs | Adverse Events |
|---|---|---|
| Boloni (2016) [41] | 4/18 (22.2%) | Discomfort was not observed except for a patient who suffered from a mild headache after receiving active stimulation. |
| Gómez (2020) [20] | NR | Serious AEs were not reported. There were no seizures, syncopes, neurological complications or subjective complaints about memory or concentration impairment limiting the treatment. |
| Hanlon (2015) [15] | NA | NR |
| Hanlon (2017) [42] | NA | NR |
| Madeo (2020) [43] | 58/284 (20.4%) | AEs were reported by 41 of the 284 patients. AEs reported were headache (n = 23), hypomania (n = 4), anxiety (n = 2), irritability (n = 2), dental pain (n = 2), scalp discomfort during the first 2 (n = 1), angioedema and urticaria (n = 1), distractibility (n = 1), dizziness (n = 1), nausea (n = 1), nausea and numbness (n = 1), seizure (n = 1), and a hypomanic episode (n = 1). |
| Martínez (2018) [44] | NR | Participants had difficulty tolerating stimulation that increased from 100 to 120% of MT, and thus the protocol was amended by lowering the maximal stimulation. |
| Pettorruso (2019) [45] | 4/20 (20%) | The treated subjects reported no significant side effect. |
| Politi (2008) [46] | NR | NR |
| Rapinesi (2016) [17] | 0/7 (0%) | All patients tolerated the stimulation without complications or AEs. |
| Sanna (2019) [47] | 4/47 (8.5%) | A few participants in both the 15 Hz rTMS and the iTBS groups reported mild discomfort at the start of stimulation, especially during the first session. Both treatments were safe and there were no serious or unexpected AEs related to the treatments. There were no seizures or any other transient neurological event. |
| Steele (2019) [48] | 7/16 (43.7%) | There were no unexpected, serious AEs. Nine of the 14 participants experienced at least one headache. One participant experienced sudden pain around her eyes and one experienced muscle soreness in the right forearm. No negative side-effects in cognitive and affective assessments were reported. No participant experienced any signs of mania or suicidality. After completing 26 iTBS sessions, a participant reported right-hand supination/pronation and thus treatment was terminated. |
| Terraneo (2016) [13] | 3/32 (9.4%) | A few participants reported mild discomfort at the start of stimulation, especially during the first session, but overall, there were no significant differences in AEs across groups. There were no serious or unexpected AEs. |
| AEs: adverse events; NR: not reported; NA: not applicable. | ||