Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2021 Dec 3;22(23):13087. doi: 10.3390/ijms222313087

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

PMC Copyright notice

Proportion of specific cell cycle phases after PD-L1 knockdown. In the six different HNSCC cell lines (i.e., PCI 1, 9, 13, 8, 15, and 52), PD-L1 levels were reduced after siRNA knockdown (KD). Transfection with non-targeting siRNA (NT) served as the control. (A) Stacked bar charts show the percentage of cells in the G1, S, or G2/M phase. All three phases together sum up to 100%. (B) For statistical analysis, PD-L1 KD samples of the three epithelial and three mesenchymal cell lines were compared with their respective NT controls, using ratio paired t-tests (ns = p ≥ 0.05; * = p < 0.05). n = 3. KD efficiency is shown in Supplementary Materials Figure S3. The effect on the proliferation rate of epithelial HNSCCs is shown in Supplementary Materials Figure S4, while the effect on mesenchymal HNSCCs is shown in Schulz et al. Figure 5 [25].

Proportion of specific cell cycle phases after PD-L1 knockdown. In the six different HNSCC cell lines (i.e., PCI 1, 9, 13, 8, 15, and 52), PD-L1 levels were reduced after siRNA knockdown (KD). Transfection with non-targeting siRNA (NT) served as the control. (A) Stacked bar charts show the percentage of cells in the G1, S, or G2/M phase. All three phases together sum up to 100%. (B) For statistical analysis, PD-L1 KD samples of the three epithelial and three mesenchymal cell lines were compared with their respective NT controls, using ratio paired t-tests (ns = p ≥ 0.05; * = p < 0.05). n = 3. KD efficiency is shown in Supplementary Materials Figure S3. The effect on the proliferation rate of epithelial HNSCCs is shown in Supplementary Materials Figure S4, while the effect on mesenchymal HNSCCs is shown in Schulz et al. Figure 5 [25].