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. 2021 Nov 23;10(23):5468. doi: 10.3390/jcm10235468

Figure 4.

Figure 4

Mechanisms of action of the most commonly used antifungals. AMB—amphotericin B, NAT—natamycin, VCZ—voriconazole. AMB binds to the cell membrane ergosterol, which results in the formation of pores and an increase in the membrane permeability. Binding of NAT to the ergosterol leads to inhibition of glucose and amino acids transport trough adequate membranes transporters. VCZ blocks 14-α-demethylase/cytochrome P450 complex, which leads to a decrease in transformation of 14-α-lanosterol to ergosterol and, as a result, destabilization of the cell membrane.