Table 1.

Effects of estetrol on the estrogen receptor α (ERα) and β (ERβ) on different tissues: brain, bone, female genital system, and breast.

	Low affinity for estrogen receptors [12,13] Higher affinity for ERα than ERβ [10] A natural SERM [24,27,28]
	Neuroprotective effects [19,20] Inhibition of LH and FSH secretion [8,18,19]
	Prevention of bone demineralization [18] Increase bone mineral density [18]
	Inhibition of ovulation [30] Uterine growth and epithelial proliferation [16,31,32]
	Less known Estrogenic and anti-estrogenic effects on horizontal migration and matrix invasion of ER+ T47-D [19,30,33]