Table 2.
Effects of quinolones and related molecules, different from anti-bacterials.
| Agent | Effect | Reference |
|---|---|---|
| (As Anti-Parasitic) | ||
| Fluorinated quinone amides | Antiparasitic, anti-trypanosomal | [122] |
| Metal complexes with FQs | Antiparasitic | [92] |
| Methyl quinolones-derivates | Antiparasitic | [123] |
| (As Anti-Viral) | ||
| Enrofloxacin, ofloxacin, orbifloxacin, iprofloxacin | Activity anti-HCV | [103] |
| Fluoroquinolone-isatin hybrids | Anti-HIV and anti-HCV activities | [124] |
| Quinolones derivates molecules | HIV-1 integrase inhibitors | [125] |
| (As Anti-Fungal) | ||
| Quinolone derivates molecules | Anti-fungal activity against A. flavus | [98] |
| Clinafloxacin triazole hybrids | Anti-fungal activity against C. albicans and C. mycoderma | [94] |
| (As Anti-Inflammatory) | ||
| Ciprofloxacin Levofloxacin |
Anti-inflammatory. Inhibition of microglia inflammatory response | [110] |
| Moxifloxacin | Immunomodulatory activity. Reduces secretion of IL-α and TNF-α. Anti-inflammatory. Inhibited ERK1/2, p38 and p65-NFκB. Inhibits etoposide pro-inflammatory effects | [111,112,113] |
| (As Anti-Cancer/Anti-Tumor) | ||
| Moxifloxacin | Activity anti-tumor (Cooper complexes) | [119] |
| Ciprofloxacin and other FQs | Cell cycle arrest and induction of apoptosis | [115,116,117] |
| Ruthenium complex with quinolones | Anti-cancer | [126] |
| (With Other Effects) | ||
| Enrofloxacin, ofloxacin, orbifloxacin, ciprofloxacin | Inhibitory effects on CYP3A in Dogs | [127] |
| Ciprofloxacin and enoxacin | Competitive inhibitory of CYP1A2 | [78] |
| (Quinolones-Related Molecules) | ||
| Quinazolinones related compounds | Anti-convulsant | [128] |
| Quinolines | Neuroprotective, Diuretic activity | [129,130] |