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. 2021 Nov 29;26(23):7241. doi: 10.3390/molecules26237241

Table 1.

In vitro inhibition of molecules against HDAC1, HDAC3, and HDAC6.

Comp. IC50 a (μM) ± SD
HDAC1 HDAC3 HDAC6
graphic file with name molecules-26-07241-i001.jpg
9a n = 5, X = CH2 2.31 ± 0.46 2.20 ± 0.29 1.98 ± 0.69
9b n = 6, X = CH2 0.38 ± 0.14 0.47 ± 0.01 1.46 ± 1.02
9c n = 7, X = CH2 1.13 ± 0.03 1.06 ± 0.20 3.67 ± 1.02
9d n = 8, X = CH2 0.72 ± 0.18 0.75 ± 0.06 2.94 ± 0.62
9e n = 6, X = CO 2.70 ± 0.36 0.33 ± 0.01 0.42 ± 0.18
graphic file with name molecules-26-07241-i002.jpg
15a n = 5, X = CH2 0. 28 ± 0.02 0.27 ± 0.04 5.96 ± 1.43
15b n = 6, X = CH2 0.57 ± 0.04 0.58 ± 0.04 1.67 ± 0.41
15c n = 8, X = CH2 0.82 ± 0.06 0.96 ± 0.13 3.09 ± 0.54
15d n = 5, X = CO 0.44 ± 0.10 0.22 ± 0.02 5.28 ± 1.42
graphic file with name molecules-26-07241-i003.jpg
21a X = CH2 1.60 ± 0.54 0.56 ± 0.02 >20
21b X = CO 1.20 ± 0.44 0.28 ± 0.04 >20
graphic file with name molecules-26-07241-i004.jpg
23a X = CH2 8.32 ± 2.10 0.65 ± 0.03 0.38 ± 0.10
23b X = CO 2.23 ± 0.30 0.76 ± 0.10 >20
SAHA b 0.24 ± 0.04 0.14 ± 0.02 0.20 ± 0.02

a Data are the mean ± SD value of three independent determinations. b Positive control.