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. 2021 Nov 25;26(23):7128. doi: 10.3390/molecules26237128

Figure 1.

Figure 1

FO reduced ROS through Nrf2/Ho-1 in the gastrocnemius muscle atrophy induced mouse model; (a) The mRNA levels of nrf2 were decreased by Dexa/Saline but increased by GABA, lactate, GABA+lactate, and FO treatment; (b) The mRNA levels of keap1 were increased by Dexa/Saline but decreased by GABA, lactate, GABA+lactate, and FO treatment; (c) Relative NADP/NDPH ratios were increased by Dexa/Saline but decreased by GABA, lactate, GABA+lactate, and FO treatment; (d) The mRNA levels of ho-1 were decreased by Dexa/Saline but increased by GABA, lactate, GABA+lactate, and FO treatment; (e,f) SOD activity (e) and total glutathione (f) were decreased by Dexa/Saline but increased by GABA, lactate, GABA+lactate, and FO treatment. Different letters, a–g, indicate significant differences among the group as determined by multiple comparisons (Mann-Whitney U test); p < 0.05; fermented oyster extracts (FO); γ-aminobutyric acid (GABA); heme oxygenase (ho-1); gastrocnemius (gastroc.); kelch-like ECH-associated protein 1 (keap1); nicotinamide adenine dinucleotide phosphate (NADP); nicotinamide adenine dinucleotide phosphate hydrate (NADPH); nuclear factor erythroid-2-related factor 2 (nrf); superoxide dismutase (SOD).