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. 2021 Nov 25;26(23):7128. doi: 10.3390/molecules26237128

Figure 3.

Figure 3

FO reduced muscle proteolysis through IGF-1 in a muscle atrophy-induced mouse model. (a) The mRNA levels of cbl-b were increased by Dexa/Saline but decreased by GABA, lactate, GABA+lactate, and FO treatment; (b) The mRNA levels of igf-1 were decreased by Dexa/Saline but increased by GABA, lactate, GABA+lactate, and FO treatment; (c–e) The mRNA levels foxo3a (c), atrogin-1 (d), and murf1 (e), were increased by Dexa/Saline but decreased by GABA, lactate, GABA+lactate, and FO treatment. a–e Different letters indicate significant differences among groups as determined by multiple comparisons (Mann-Whitney U test); p < 0.05. a muscle-specific F-box protein (atrogin-1); Cbl Proto-Oncogene B (cbl-b); fermented oyster extracts (FO); γ-aminobutyric acid (GABA); gastrocnemius (gastroc); forkhead box O3 (foxO3a); insulin-like growth factor 1 (igf-1); Muscle RING-finger protein-1 (murf1).