Table 1.
Antifungal activity (MIC100 for Yarrowia lipolytica, MIC90 for molds, and MIC80 for yeasts) of six novel 4-aminopiperidine derivatives, amorolfine hydrochloride (A), and voriconazole (V) against the model strain Y. lipolytica and clinically relevant fungal species; () = tested fungal isolates in total.
| Strain | MIC Values [µg/mL] | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Compound | A | V | 2b | 2c | 3b | 4b | 5b | 6a | |
| Model strain | Y. lipolytica (1) | 0.6 | 0.4 | 2 | 25 | 0.8 | 3 | 5 | 75 |
| Aspergillus spp. | A. flavus (1) | >16 | 0.25 | 16 | >16 | 4–8 | 16 | 16 | >16 |
| A. fumigatus (2) | >16 | 0.125 | 8 | >16 | 2–8 | 16 | 16 | >16 | |
| A. terreus (2) | 8–16 | 0.125 | 4–8 | 8–16 | 1–2 | 8 | 4–8 | 4–8 | |
| Candida spp. | C. auris (1) | 16 | >16 | 4 | 64 | 2–4 | 16 | 8 | >16 |
| C. glabrata (1) | >16 | >16 | 4 | 32 | 1–4 | 8–16 | 4–8 | >16 | |
| C. krusei (5) | 1–>16 | 0.5–>16 | 2–4 | 2–64 | 1–4 | 1–16 | 4–8 | >16 | |
|
Mucor-
mycetes |
A. elegans (1) | 16 | >16 | >16 | >16 | 8 | >16 | >16 | >16 |
| L. corymbifera (1) | 16 | >16 | >16 | >16 | >16 | >16 | >16 | 16 | |
| L. ramosa (1) | 8 | 8 | 8 | >16 | 8 | 16 | 16 | >16 | |
| M. circinelloides (1) | 16 | >16 | 16 | >16 | 4 | 16 | 16 | 16 | |
| R. arrhizus (1) | 8 | 16 | 16 | >16 | 8 | >16 | 16 | >16 | |
| R. microsporus (2) | 8 | 16 | 8 | >16 | 8 | 16 | 8 | 16 | |
| S. racemosum (1) | 16 | >16 | >16 | >16 | >16 | >16 | >16 | 16 | |