Table 2.
Antifungal activity of amorolfine hydrochloride (A), 2b, and 3b against clinical isolates (Aspergillus and Candida species). MIC ranges represent the MIC90 values obtained for 6 Aspergillus isolates and the MIC80 values obtained for 6–7 isolates of each Candida species in all experiments. MFC ranges represent the MFCs determined for selected Aspergillus (1 per species) and Candida (1 isolate of C. albicans and C. tropicalis and 2 isolates of C. glabrata and C. krusei) isolates; () = tested fungal isolates in total. All experiments were carried out in duplicates.
| Strain | MIC Ranges (µg/mL) | MFC Ranges (µg/mL) | |||||
|---|---|---|---|---|---|---|---|
| Compound | A | 2b | 3b | A | 2b | 3b | |
| Aspergillus spp. | A. flavus (6) | >16 | 8–16 | 8–16 | >16 | 16 | 16 |
| A. fumigatus (6) | >16 | 8–16 | 4–8 | >16 | 16 | 16 | |
| A. terreus (6) | >16 | 8–16 | 4–16 | >16 | 16 | 16 | |
| Candida spp. | C. albicans (6) | 4–16 | 4–8 | 2–4 | >16 | 8 | 4–8 |
| C. glabrata (7) | 4–>16 | 4–8 | 1–4 | >16 | 4–8 | 2–8 | |
| C. krusei (6) | 0.5–>16 | 2–4 | 1–4 | 16–>16 | 4–8 | 2–4 | |
| C. tropicalis (6) | 8–>16 | 4–8 | 2–4 | >16 | 8 | 8 | |