Table 2.

Uncertainties associated with the modeled exposure rates (in percentage of central-tendency estimate) via exposure routes from the far-field environment, as a result of the propagation of uncertainties in partitioning (equilibrium partition coefficients) and reactive properties (air hydroxylation rate constant, primary biodegradation half-life, and whole-body biotransformation half-lives in fish and mammals) predicted by the QSARs and QSPRs adopted by PROTEX-HT, arrayed by assumed mode of entry.

Mode of entry	Input parameter	Inhalation of outdoor air (%)	Drinking ingestion (%)	Dietary ingestion (%)
100% to air	Overall	58	418	352
	$K_{\text{OA}}$	27	60	179
	$K_{\text{OW}}$	3	10	143
	$k_{\text{OH}}$	27	27	27
	$H{L}_{\text{biodeg}}$	0	321	0
	$H{L}_{\text{fish}}$	0	0	0
	$H{L}_{\text{mammal}}$	0	0	3
100% to water	Overall	1,106	326	596
	$K_{\text{OA}}$	750	0	2
	$K_{\text{OW}}$	13	10	175
	$k_{\text{OH}}$	27	0	0
	$H{L}_{\text{biodeg}}$	317	316	316
	$H{L}_{\text{fish}}$	0	0	102
	$H{L}_{\text{mammal}}$	0	0	0
100% to soil	Overall	1,144	1,257	1,048
	$K_{\text{OA}}$	248	1	4
	$K_{\text{OW}}$	548	529	717
	$k_{\text{OH}}$	27	0	1
	$H{L}_{\text{biodeg}}$	322	727	326
	$H{L}_{\text{fish}}$	0	0	0
	$H{L}_{\text{mammal}}$	0	0	0

Note: HT, high throughput; PROTEX, PROduction-To-EXposure; QSAR, quantitative structure–activity relationship; QSPR, quantitative structure–property relationship.