Table 3.

Uncertainties associated with the modeled exposure rates (in percentage of central-tendency estimate) via exposure routes from the near-field environment, as a result of the propagation of uncertainties in partitioning (equilibrium partition coefficients) and reactive properties (air hydroxylation rate constant, primary biodegradation half-life, and whole-body biotransformation half-lives in fish and mammals) predicted by the QSARs and QSPRs adopted by PROTEX-HT, arrayed by assumed mode of entry.

Mode of entry	Input parameter	Inhalation of indoor air (%)	Dermal absorption (%)	Mouthing-mediated ingestion (%)
100% to air	Overall	67	889	2,854
	$K_{\text{OA}}$	35	738	1,501
	$K_{\text{OW}}$	28	141	1,339
	$k_{\text{OH}}$	5	10	14
	$H{L}_{\text{biodeg}}$	0	0	0
	$H{L}_{\text{fish}}$	0	0	0
	$H{L}_{\text{mammal}}$	0	0	0
100% to human skin	Overall	121	708	913
	$K_{\text{OA}}$	70	405	483
	$K_{\text{OW}}$	46	301	428
	$k_{\text{OH}}$	4	2	2
	$H{L}_{\text{biodeg}}$	0	0	0
	$H{L}_{\text{fish}}$	0	0	0
	$H{L}_{\text{mammal}}$	0	0	0

Note: HT, high throughput; PROTEX, PROduction-To-EXposure; QSAR, quantitative structure–activity relationship; QSPR, quantitative structure–property relationship.