TABLE 1.
Isoelectric points and susceptibilities of AmpC-producing isolates
| Isolate | pIa | MICb (μg/μl)
|
|||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AMP | FOX | FOX-Ro(4) | CPD | CPD-Cl(4) | CRO | CRO-Cl(2) | CTX | CAZ | AZT | CEF | IMI | ||
| E. coli | |||||||||||||
| M477 | 9.1 | 256 | 32 | 8 | 128 | 128 | 16 | 16 | 8 | 128 | 16 | 4 | 0.13 |
| M491 | 9.1 | 512 | 64 | 16 | 128 | 128 | 4 | 4 | 8 | 32 | 16 | 0.13 | 0.13 |
| M483 | 9.1 | 512 | 32 | 8 | 512 | 256 | 16 | 16 | 16 | 64 | 16 | 0.5 | 0.13 |
| M540 | 9.0, 5.4 | 4,096 | 128 | 32 | 128 | 128 | 2 | 1 | 4 | 4 | 16 | 0.13 | 0.06 |
| M545B | 9.0 | 512 | 64 | 16 | 128 | 64 | 1 | 1 | 4 | 4 | 16 | 0.06 | 0.06 |
| M563c | 9.1 | 265 | 32 | 2 | 128 | 64 | 1 | 0.5 | 2 | 4 | 8 | 0.03 | 0.13 |
| M656 | 9.1 | 64 | 8 | 2 | 8 | 4 | 0.13 | 0.13 | 0.5 | 0.5 | 1 | 0.06 | 0.13 |
| M683 | 9.0 | 64 | 8 | 2 | 8 | 8 | 0.13 | 0.06 | 0.5 | 0.5 | 1 | 0.02 | 0.06 |
| M752 | 7.2, 5.6 | >4,096 | 64 | 32 | 128 | 128 | 2 | 2 | 8 | 32 | 1 | 0.06 | 0.13 |
| M804 | 9.0 | 256 | 32 | 4 | 128 | 64 | 1 | 0.5 | 2 | 2 | 2 | 0.03 | 0.13 |
| M809 | 9.0 | 512 | 128 | 4 | 512 | 512 | 32 | 32 | 16 | 32 | 16 | 0.13 | 0.13 |
| K. pneumoniae | |||||||||||||
| M484 | 7.2, 5.6 | >4,096 | 1,024 | 1,024 | 2,048 | 2,048 | 64 | 32 | 32 | 256 | 8 | 4 | 1.0 |
| M621 | 7.2, 5.6, 7.8 | >4,096 | 64 | 64 | 128 | 128 | 8 | 4 | 16 | 64 | 16 | 0.25 | 0.13 |
| M625B | 7.2, 5.6, 7.8 | >4,096 | 128 | 64 | 256 | 128 | 8 | 4 | 8 | 64 | 32 | 0.5 | 0.13 |
| M846 | 7.2, 5.6 | >4,096 | 64 | 64 | 256 | 256 | 8 | 8 | 16 | 64 | 4 | 0.5 | 0.25 |
| P. mirabilisM910 | 9.0 | 128 | 16 | 2 | 256 | 256 | 2 | 2 | 4 | 1 | 0.25 | 0.13 | 4.0 |
The first isoelectric points correspond to those for the cloxacillin-inhibited band (AmpC); additional pIs correspond to those for clavulanic acid-inhibited bands.
AMP, ampicillin; FOX, cefoxitin; FOX-Ro(4), cefoxitin plus 4 μg of Ro 48-1220 per ml; CPD, cefpodoxime; CPD-Cl(4), cefpodoxime plus 4 μg of clavulanic acid per ml; CRO, ceftriaxone; CRO-Cl(2), ceftriaxone plus 2 μg clavulanic acid per ml; CTX, cefotaxime; CAZ, ceftazidime; AZT, aztreonam; CEF, cefepime; IMI, imipenem.
Resistance was transferred for the underlined isolates.