Table 4.

Nanocurcumin in patent reviews.

S. No.	Patent No.	Study Title	Interventions	References
1	US 9, 931, 309 B2	Complex curcumine-sophorolipids	Nanoencapsulated in acidic sophorolipids to enhance curcumin’s bioavailability and solubility to boost its pharmacological response, including cancer	[223]
2	US20180028447	Development of curcumin and piperine loaded double-layered biopolymer based nano delivery systems by using electrospray/coating method	Curcumin was contained in the core network, which was made up of zein protein, and piperinewas encased in the outermost casing, which was chitosan. Although the precise method emphasizing the molecular mechanism of piperine for curcumin improvement was not defined, it was demonstrated that decreasing the efficiency of cytochrome P4503A4 (CYP3A4), which plays a role in curcumin metabolism, enhanced the residence duration of curcumin.	[224]
3	US20100290982A1	Solid in oil/water emulsion-diffusion-evaporation formulation for preparing curcumin-loaded PLGA nanoparticles	Findings were obtained by producing the solid in oil/water emulsion diffusion evaporation composition for generating curcumin-loaded PLGA nanoparticles.	[225]
4	US10413511B2	Liposomal formulations of lipophilic compounds	Revealed unique preparations for curing refractory and resistant pancreatic malignancies with a paclitaxel in a cationic liposomal form; gemcitabine, a ribonucleotide reductase inhibitor that prevents DNA synthesis in cancerous cells; and other anticancer drugs	[226]
5	US9138411B2	Curcumin-ER, a liposomal-PLGA sustained release nanocurcumin for minimizing QT prolongation for cancer therapy	The bioactive substance curcumin and curcumin–PLGA analogues were utilized in the liposome, which consisted of a polymeric core with ground lipidic components. Human embryonic kidney (HEK 293) cell lines treated with the human ether-related gene (hERG) were used to test it. The whole-cell patch-clamp present review and approval approach was used to examine the in vitro consequences of the curcumin liposomal preparation of potassium-selective IKr currents produced in normoxia in stably transfected HEK 293 cells.	[227]
6	US9283185B2	Liposomal curcumin for treatment of cancer	In human patients, curcumin analogues and curcumin enclosed as liposomal preparations were revealed to treat pancreatic cancer, breast cancer, and melanoma.	[228]
7	WO 2013132457	Nanocrystalline solid dispersion compositions and process of preparation thereof	A curcumin–stearic acid mixture was produced and nebulized by spray-drying to create a dry powder to produce nanocrystalline solid dispersion. Oral dosing of spray-dried curcumin and curcumin–stearic acid nanocrystalline solid dispersion in rats resulted in a 15-fold increase in curcumin oral bioavailability with nanocrystalline solid dispersion compared to the control.	[229]