Table 2.

In vitro cholinesterase inhibition potential of curcumin analogs.

Comp.	Conc. µg/mL	Mean ± SEM	AChEI (IC50)	Mean ± SEM	BChEI (IC50)
h1	1000	79.67 ± 0.21 ns	104.72	62.16 ± 0.04 ***	243.12
	500	68.07 ± 0.18 ***		56.42 ± 0.16 ***
	250	58.12 ± 0.16 ***		51.91 ± 0.14 ***
	125	54.34 ± 0.17 ***		46.25 ± 0.13 ***
	62.5	45.63 ± 0.13 ***		37.16 ± 0.12 ***
h2	1000	76.23 ± 0.15 ns	93.27	69.77 ± 0.03 ***	147.92
	500	73.79 ± 0.12 ns		64.38 ± 0.06 ***
	250	61.21±0.18 ***		57.22 ± 0.01 ***
	125	53.57 ± 0.17 ***		48.61 ± 0.15 ***
	62.5	46.88 ± 0.15 ***		41.82 ± 0.18 ***
h3	1000	83.31 ± 0.13 ns	29.39	78.72 ± 0.16 *	67.35
	500	77.25 ± 0.11 ns		69.52 ± 0.12 ***
	250	69.51 ± 0.13 ns		62.41 ± 0.19 ***
	125	62.44 ± 0.16 ns		58.33 ± 0.13 ***
	62.5	53.53±0.12 *		49.25 ± 0.02 ***
h4	1000	63.51 ± 0.17 ***	294.77	56.32 ± 0.18 ***	512.77
	500	58.16 ± 0.11 ***		49.51 ± 0.16 ***
	250	46.32 ± 0.15 ***		42.62 ± 0.12 ***
	125	39.45 ± 0.04 ***		35.33 ± 0.19 ***
	62.5	31.41 ± 0.13 ***		27.16 ± 0.11 ***
h5	1000	58.41 ± 0.13 ***	632.37	51.82 ± 0.16 ***	988.35
	500	47.33 ± 0.16 ***		43.51 ± 0.13 ***
	250	41.27 ± 0.04 ***		32.73 ± 0.01 ***
	125	35.51 ± 0.06 ***		20.26 ± 0.31 ***
	62.5	26.45 ± 0.18 ***		16.22 ± 0.83 ***
Galanthamine	1000	81.85 ± 0.18	26.58	83.53 ± 0.20	21.30
	500	76.59 ± 0.30		78.62 ± 0.17
	250	69.75 ± 0.14		73.42 ± 0.11
	125	64.47 ± 0.49		66.20 ± 0.15
	62.5	59.12 ± 0.34		61.35 ± 0.18

All values are presented as mean ± SEM, (n = 3). Galanthamine was used as standard control. Significantly different values are with reference to the standard control; p-value <0.001, <0.01, <0.05, >0.05 are expressed as ***, **, * and ‘ns’, respectively.