Table 3.

Effect of synthesized curcumin analogs h1–h5 on alteration behavior and transfer latency in mice.

Samples	Treatment/Dose	Retention (sec)
Control	Normal saline, p.o	36.42 ± 1.81
Scopolamine (Scop)	1 mg/kg, i.p negative control	67.31 ± 1.24 ***
Donepezil (DZP)	2 mg/kg p.o	25.57 ± 1.93 ***
h1	7.5 mg/kg, p.o	33.13 ± 2.16 *
	15 mg/kg, p.o	26.18 ± 2.32 ***
h2	7.5 mg/kg, p.o	31.51 ± 2.73 **
	15 mg/kg, p.o	25.32 ± 2.42 ***
h3	7.5 mg/kg, p.o	25.26 ± 2.51 ***
	15 mg/kg, p.o	21.27 ± 2.92 ***
h4	7.5 mg/kg, p.o	35.71 ± 1.13 *
	15 mg/kg, p.o	30.42 ± 1.24 **
h5	7.5 mg/kg, p.o	34.71 ± 1.37 *
	15 mg/kg, p.o	31.51 ± 1.54 **

All values are presented as mean ± SEM (n = 6), p < 0.001 vs. normal control. Positive control and tested samples received Scopolamine 1 mg/kg i.p. Significantly different values are with reference to the scopolamine-treated group; p-value <0.001, <0.01, <0.05 are expressed as ***, **, * respectively. One-way ANOVA followed by Dunnett’s multiple comparison tests was applied on these data.