Table 3.
Correlation between Serum Chemokines and Laboratory Data before Bath PUVA Therapy
| WBC | Neutrophils | Lymphocytes | Monocytes | Eosinophils | Hemoglobin | Platelets | IL-6 | CRP | ESR | |
|---|---|---|---|---|---|---|---|---|---|---|
| PASI | 0.474 (0.0258 – 0.764) | 0.572 (0.160 – 0.815) | 0.157 (–0.319 to 0.570) | 0.314 (–0.163 to 0.672) | –0.0331 (–0.480 to 0.427) | –0.183 (–0.588 to 0.296) | 0.356 (–0.116 to 0.697) | –0.0613 (–0.538 to 0.445) | 0.304 (–0.241 to 0.703) | –0.0939 (–0.536 to 0.389) |
| CCL2 | 0.108 (–0.364 to 0.535) | 0.226 (–0.254 to 0.616) | –0.0962 (–0.527 to 0.374) | –0.00902 (–0.461 to 0.447) | 0.227 (–0.253 to 0.617) | –0.231 (–0.620 to 0.249) | 0.318 (–0.159 to 0.674) | –0.103 (–0.567 to 0.410) | 0.328 (–0.216 to 0.716) | 0.0863 (–0.395 to 0.531) |
| CCL3 | 0.370 (–0.101 to 0.705) | 0.376 (–0.0938 to 0.709) | 0.262 (–0.218 to 0.639) | 0.444 (–0.0127 to 0.747) | –0.0406 (–0.485 to 0.421) | 0.422 (–0.0389 to 0.735) | 0.163 (–0.314 to 0.574) | –0.0588 (–0.536 to 0.447) | 0.154 (–0.384 to 0.613) | 0.117 (–0.369 to 0.553) |
| CCL4 | 0.178 (–0.300 to 0.584) | 0.287 (–0.191 to 0.656) | –0.108 (–0.536 to 0.363) | 0.138 (–0.337 to 0.557) | 0.147 (–0.328 to 0.563) | 0.301 (–0.177 to 0.664) | 0.339 (–0.135 to 0.687) | –0.0686 (–0.543 to 0.439) | –0.0177 (–0.521 to 0.494) | 0.128 (–0.359 to 0.560) |
| CCL5 | –0.138 (–0.557 to 0.337) | – 0.0466 (–0.490 to 0.416) | –0.184 (–0.588 to 0.295) | –0.0541 (–0.496 to 0.410) | –0.171 (–0.580 to 0.306) | 0.257 (–0.223 to 0.636) | 0.0527 (–0.411 to 0.495) | –0.302 (–0.691 to 0.224) | 0.112 (–0.419 to 0.587) | 0.0247 (–0.446 to 0.485) |
| CCL11 | 0.278 (–0.201 to 0.650) | 0.310 (–0.168 to 0.669) | 0.134 (–0.341 to 0.554) | 0.202 (–0.278 to 0.600) | 0.0165 (–0.441 to 0.467) | –0.361 (–0.700 to 0.111) | 0.358 (–0.114 to 0.698) | –0.125 (–0.582 to 0.392) | 0.536 (0.0391 – 0.821) | 0.369 (–0.116 to 0.712) |
| CCL17 | 0.537 (0.110 – 0.797) | 0.672 (0.314 – 0.863) | 0.0872 (–0.382 to 0.520) | 0.343 (–0.131 to 0.689) | 0.334 (–0.141 to 0.684) | –0.434 (–0.742 to 0.0242) | 0.527 (0.0959 – 0.791) | 0.382 (–0.136 to 0.736) | 0.498 (–0.0133 to 0.803) | 0.397 (–0.0848 to 0.728) |
| CCL18 | 0.153 (–0.323 to 0.567) | 0.202 (–0.278 to 0.600) | –0.0346 (–0.481 to 0.426) | –0.119 (–0.543 to 0.354) | 0.0827 (–0.386 to 0.517) | –0.0625 (–0.502 to 0.403) | 0.317 (–0.160 to 0.674) | 0.00980 (–0.485 to 0.500) | –0.0118 (–0.516 to 0.499) | –0.0960 (–0.538 to 0.387) |
| CCL19 | 0.281 (–0.198 to 0.651) | 0.457 (0.00428 – 0.754) | –0.165 (–0.576 to 0.312) | 0.108 (–0.363 to 0.536) | 0.143 (–0.332 to 0.560) | –0.217 (–0.610 to 0.263) | 0.424 (–0.0364 to 0.736) | 0.260 (–0.267 to 0.667) | 0.273 (–0.272 to 0.686) | 0.198 (–0.295 to 0.608) |
| CCL20 | 0.339 (–0.135 to 0.687) | 0.420 (–0.0422 to 0.734) | –0.0436 (–0.488 to 0.418) | 0.0752 (–0.392 to 0.511) | 0.429 (–0.0313 to 0.739) | –0.442 (–0.746 to 0.0149) | 0.515 (0.0795 – 0.785) | 0.378 (–0.141 to 0.734) | 0.387 (–0.150 to 0.748) | 0.432 (–0.0424 to 0.747) |
| CCL21 | 0.152 (–0.324 to 0.567) | 0.0376 (–0.423 to 0.483) | 0.296 (–0.182 to 0.661) | –0.0211 (–0.470 to 0.437) | 0.305 (–0.172 to 0.667) | –0.0459 (–0.489 to 0.417) | 0.0421 (–0.420 to 0.487) | –0.0319 (–0.516 to 0.468) | –0.301 (–0.702 to 0.244) | –0.120 (–0.555 to 0.366) |
| CCL22 | 0.158 (–0.319 to 0.571) | 0.104 (–0.367 to 0.532) | 0.104 (–0.367 to 0.532) | 0.108 (–0.363 to 0.536) | 0.206 (–0.273 to 0.603) | –0.213 (–0.608 to 0.266) | 0.257 (–0.222 to 0.637) | –0.0343 (–0.518 to 0.466) | –0.0148 (–0.519 to 0.497) | 0.238 (–0.256 to 0.633) |
| CCL27 | –0.320 (–0.676 to 0.156) | –0.247 (–0.630 to 0.233) | –0.229 (–0.618 to 0.251) | –0.513 (–0.784 to 0.0769) | 0.286 (–0.193 to 0.655) | –0.0474 (–0.491 to 0.415) | –0.00677 (–0.459 to 0.448) | –0.0392 (–0.522 to 0.462) | –0.207 (–0.647 to 0.336) | –0.214 (–0.618 to 0.279) |
| CXCL1 | 0.458 (0.00545 – 0.755) | 0.588 (0.183 – 0.822) | 0.0376 (–0.423 to 0.483) | 0.289 (–0.190 to 0.656) | 0.0617 (–0.403 to 0.501) | –0.313 (–0.671 to 0.164) | 0.625 (0.239 – 0.841) | 0.206 (–0.319 to 0.634) | 0.282 (–0.263 to 0.691) | 0.530 (0.0848 – 0.798) |
| CXCL2 | 0.195 (–0.284 to 0.596) | 0.253 (–0.227 to 0.634) | –0.00752 (–0.460 to 0.448) | –0.0391 (–0.484 to 0.422) | 0.0466 (–0.416 to 0.490) | –0.354 (–0.696 to 0.119) | 0.488 (0.0444 – 0.771) | –0.0882 (–0.557 to 0.423) | 0.412 (–0.121 to 0.761) | 0.566 (0.136 – 0.816) |
| CXCL5 | 0.379 (–0.0902 to 0.711) | 0.382 (–0.0868 to 0.712) | 0.205 (–0.275 to 0.602) | 0.374 (–0.0955 to 0.708) | –0.00752 (–0.460 to 0.448) | –0.355 (–0.697 to 0.117) | 0.349 (–0.124 to 0.693) | 0.250 (–0.277 to 0.661) | 0.776 (0.442 – 0.921) | 0.451 (–0.0184 to 0.758) |
| CXCL8 | 0.160 (–0.317 to 0.572) | 0.278 (–0.201 to 0.650) | 0.0301 (–0.430 to 0.477) | 0.0737 (–0.393 to 0.510) | 0.287 (–0.191 to 0.656) | 0.294 (–0.185 to 0.659) | 0.147 (–0.329 to 0.563) | 0.260 (–0.267 to 0.667) | –0.0857 (–0.569 to 0.441) | 0.0388 (–0.435 to 0.495) |
| CXCL9 | 0.243 (–0.237 to 0.628) | 0.385 (–0.0833 to 0.714) | –0.199 (–0.598 to 0.281) | 0.0346 (–0.426 to 0.481) | 0.337 (–0.138 to 0.686) | –0.169 (–0.578 to 0.309) | 0.578 (0.168 – 0.817) | 0.304 (–0.222 to 0.693) | 0.421 (–0.110 to 0.765) | 0.298 (–0.195 to 0.670) |
| CXCL10 | –0.0226 (–0.471 to 0.436) | 0.114 (–0.358 to 0.540) | –0.209 (–0.605 to 0.270) | –0.187 (–0.590 to 0.292) | 0.438 (–0.0202 to 0.744) | –0.0580 (–0.499 to 0.406) | 0.0655 (–0.400 to 0.504) | –0.0172 (–0.505 to 0.479) | 0.127 (–0.407 to 0.596) | –0.189 (–0.602 to 0.303) |
| CXCL11 | 0.177 (–0.301 to 0.584) | 0.385 (–0.0833 to 0.714) | –0.161 (–0.573 to 0.316) | –0.0391 (–0.484 to 0.422) | –0.248 (–0.631 to 0.232) | 0.132 (–0.342 to 0.552) | 0.202 (–0.277 to 0.601) | 0.0931 (–0.419 to 0.560) | 0.464 (–0.0574 to 0.786) | 0.0943 (–0.388 to 0.536) |
| CXCL12 | –0.0613 (–0.501 to 0.404) | –0.0873 (–0.520 to 0.382) | 0.0346 (–0.426 to 0.481) | –0.0527 (–0.458 to 0.450) | –0.00827 (–0.460 to 0.447) | –0.422 (–0.735 to 0.0387) | 0.0414 (–0.420 to 0.486) | –0.191 (–0.625 to 0.332) | –0.0480 (–0.543 to 0.471) | 0.459 (–0.00813 to –0.762) |
| CXCL16 | 0.185 (–0.293 to 0.589) | 0.343 (–0.131 to 0.689) | –0.155 (–0.569 to 0.321) | –0.0376 (–0.483 to 0.423) | –0.205 (–0.602 to 0.275) | 0.0940 (–0.376 to 0.525) | 0.411 (–0.0527 to 0.729) | –0.118 (–0.577 to 0.398) | 0.0532 (–0.467 to 0.546) | –0.136 (–0.566 to 0.352) |
| CX3CL1 | –0.163 (–0.574 to 0.314) | –0.0466 (–0.490 to 0.416) | –0.218 (–0.611 to 0.262) | –0.164 (–0.575 to 0.313) | –0.158 (–0.571 to 0.319) | –0.605 (–0.831 to –0.209) | –0.0572 (–0.498 to 0.407) | –0.101 (–0.565 to 0.412) | –0.0842 (–0.568 to 0.442) | 0.263 (–0.230 to 0.649) |
Abbreviations: ESR, erythrocyte sedimentation rate; FDR, false discovery rate; WBC, white blood cell.
The P-values were adjusted using an FDR procedure and the bold showed an adjusted P < 0.05.