Table 4.
A Review of the 22 Chemokines Analyzed in this Study
| Chemokine | Receptor | Secreted Stimulation (In Vitro or In Vivo) | Putative Functions | Reference |
|---|---|---|---|---|
| Secreted from KCs | ||||
| CCL2 | CCR2 | IFN-γ, TNF-α | Monocyte and macrophage trafficking | Behfar et al. (2018) |
| CCL3 | CCR5 | Unknown | Th1 cell trafficking | Dai et al. (2014) |
| CCL4 | CCR5 | Unknown | Th1 cell trafficking | Dai et al. (2014) |
| CCL5 | CCR5 | TNF-α, IFN-γ | Th1 cell trafficking | Dai et al. (2014); Giustizieri et al. (2001) |
| CCL11 | CCR3 | Unknown | Unknown | No papers |
| CCL17 | CCR4 | TNF-α, IFN-γ | Skin homing and T-cell trafficking | Rottman et al. (2001) |
| CCL20 | CCR6 | TNF-α, IL-17 | Th17 cell and DC trafficking | Furue et al. (2020) |
| CCL22 | CCR4 | TNF-α, IFN-γ | Skin homing and T-cell trafficking | Rottman et al. (2001) |
| CCL27 | CCR10 | TNF-α, IL-1 | Skin homing and T-cell trafficking | Chen et al. (2019); Homey et al. (2002); Kakinuma et al. (2003) |
| CXCL1 | CXCR2 | IL-17 | Neutrophil trafficking | Gillitzer et al. (1996); Takei-Taniguchi et al. (2012) |
| CXCL2 | CXCR2 | IL-17, IL-36 | Neutrophil trafficking | Chiricozzi et al. (2018) |
| CXCL5 | CXCR2 | IL-17, IL-36 | Neutrophil trafficking | Chiricozzi et al. (2018) |
| CXCL8 | CXCR1,2 | IL-17 | Neutrophil trafficking | Takei-Taniguchi et al. (2012) |
| CXCL9 | CXCR3 | TNF-α, IFN-γ | Th1 cell trafficking | Rottman et al. (2001) |
| CXCL10 | CXCR3 | TNF-α, IFN-γ | Th1 cell trafficking | Rottman et al. (2001) |
| CXCL11 | CXCR3 | IFN-α | Th1 cell trafficking | Johansen et al. (2017) |
| CXCL16 | CXCR6 | TNF-α, IFN-γ | CD8+ T-cell trafficking Neutrophil trafficking |
Günther et al. (2012); Steffen et al. (2018) |
| Secreted from DCs | ||||
| CCL18 | CCR8 | Unknown | T-cell trafficking | Zhou et al. (2003) |
| CCL19 | CCR7 | Unknown | DC and T-cell trafficking and promoting the formation of secondary lymphoid tissue | Mitsui et al. (2012); Zhou et al. (2003) |
| CCL21 | CCR7 | Unknown | DC and T-cell trafficking and promoting the formation of secondary lymphoid tissue | Zhou et al. (2003) |
| CXCL16 | CXCR6 | Type-I IFN, TNF-α | CD8+ T-cell trafficking Neutrophil trafficking |
Günther et al. (2012); Steffen et al. (2018) |
| Secreted from monocytes/macrophages | ||||
| CCL18 | CCR8 | Unknown | T-cell trafficking | Zhou et al. (2003) |
| CXCL16 | CXCR6 | Type-I IFN, TNF-α | CD8+ T-cell trafficking Neutrophil trafficking |
Günther et al. (2012); Steffen et al. (2018) |
| Secreted from ECs | ||||
| CCL17 | CCR4 | TNF-α, IFN-γ | Skin homing and T-cell trafficking | Rottman et al. (2001) |
| CX3CL1 | CX3CR1 | TNF-α, IFN-γ | Th1 polarization, NK cells trafficking | Fraticelli et al. (2001) |
| Secreted from fibroblasts | ||||
| CXCL12 | CXCR4 | Unknown | Keratinocyte proliferation | Quan et al. (2015) |
Abbreviations: DC, dendritic cell; EC, endothelial cell, KC, keratinocyte; Th, T helper.