Table 3.
ORs (95% CI) for BSA ≤ 1, BSA 75, IGA 0/1, PASI 90, PASI 100 Response 6 Months after Biologic Initiation in 2018 by US Geographic Region in the Corrona Psoriasis Registry
| Variables | Regions | % Responders | Unadjusted OR | Adjusted OR1 |
|---|---|---|---|---|
| BSA ≤ 1 | ||||
| Northeast | 100/218 (49.3%) | Ref | Ref | |
| Pacific | 55/100 (55.0%) | 1.33 (0.81–2.16) | 1.13 (0.65–1.97) | |
| Mountain/West North Central | 43/95 (54.4%) | 1.22 (0.72–2.06) | 1.22 (0.71–2.09) | |
| West South Central | 18/46 (39.1%) | 0.66 (0.34–1.26) | 0.75 (0.38–1.50) | |
| East North Central | 22/48 (45.8%) | 0.86 (0.46–1.62) | 1.01 (0.53–1.93) | |
| East South Central | 41/107 (38.3%) | 0.71 (0.43–1.15) | 0.86 (0.52–1.43) | |
| South Atlantic | 42/92 (45.7%) | 0.91 (0.55–1.49) | 0.91 (0.55–1.51) | |
| BSA 75 | ||||
| Northeast | 129/213 (60.6%) | Ref | Ref | |
| Pacific | 62/103 (60.2%) | 1.01 (0.62–1.64) | 0.78 (0.45–1.37) | |
| Mountain/West North Central | 53/94 (56.4%) | 0.84 (0.51–1.37) | 0.92 (0.56–1.51) | |
| West South Central | 20/47 (42.6%) | 0.48 (0.25–0.91)2 | 0.48 (0.24–0.95)2 | |
| East North Central | 31/54 (57.4%) | 0.87 (0.48–1.60) | 0.82 (0.45–1.52) | |
| East South Central | 51/115 (44.3%) | 0.55 (0.34–0.87)2 | 0.51 (0.31–0.85)3 | |
| South Atlantic | 56/98 (57.1%) | 0.91 (0.56–1.49) | 0.94 (0.57–1.56) | |
| IGA 0/1 | ||||
| Northeast | 111/197 (56.3%) | Ref | Ref | |
| Pacific | 45/100 (45.0%) | 0.65 (0.40–1.05) | 0.57 (0.33–0.98)2 | |
| Mountain/West North Central | 44/82 (53.7%) | 0.89 (0.53–1.49) | 0.87 (0.51–1.48) | |
| West South Central | 17/44 (38.6%) | 0.48 (0.25–0.94)2 | 0.56 (0.28–1.11) | |
| East North Central | 25/47 (53.2%) | 0.87 (0.46–1.65) | 0.94 (0.49–1.81) | |
| East South Central | 39/113 (34.5%) | 0.44 (0.27–0.71)4 | 0.47 (0.29–0.79)3 | |
| South Atlantic | 49/92 (53.3%) | 0.92 (0.56–1.52) | 0.98 (0.59–1.64) | |
| PASI 90 | ||||
| Northeast | 88/212 (41.5%) | Ref | Ref | |
| Pacific | 40/103 (38.8%) | 0.92 (0.57–1.50) | 0.74 (0.43–1.29) | |
| Mountain/West North Central | 36/93 (38.7%) | 0.88 (0.54–1.45) | 0.94 (0.57–1.55) | |
| West South Central | 15/47 (31.9%) | 0.66 (0.34–1.29) | 0.75 (0.37–1.50) | |
| East North Central | 19/53 (35.8%) | 0.78 (0.42–1.46) | 0.81 (0.43–1.51) | |
| East South Central | 39/116 (33.6%) | 0.77 (0.47–1.25) | 0.81 (0.49–1.35) | |
| South Atlantic | 34/98 (34.7%) | 0.78 (0.47–1.29) | 0.74 (0.45–1.23) | |
| PASI 100 | ||||
| Northeast | 69/212 (32.5%) | Ref | Ref | |
| Pacific | 20/103 (19.4%) | 0.51 (0.29–0.90)2 | 0.45 (0.23–0.86)2 | |
| Mountain/West North Central | 25/93 (26.9%) | 0.75 (0.44–1.29) | 0.75 (0.44–1.30) | |
| West South Central | 11/47 (23.4%) | 0.63 (0.30–1.31) | 0.70 (0.33–1.47) | |
| East North Central | 14/53 (26.4%) | 0.74 (0.38–1.46) | 0.82 (0.42–1.61) | |
| East South Central | 27/116 (23.3%) | 0.66 (0.39–1.11) | 0.71 (0.41–1.23) | |
| South Atlantic | 23/98 (23.5%) | 0.65 (0.38–1.14) | 0.62 (0.35–1.09) | |
Abbreviations: BMI, body mass index; BSA 75, 75% improvement in BSA; BSA, body surface area; CI, confidence interval; IGA, Investigator’s Global Assessment; PASI 100, achieving 100% PASI; PASI 90, achieving 90% PASI; Ref, reference; US, United States.
1
Adjusted for age, sex, race, BMI, and baseline BSA.
2
Significant at P < 0.05.
3
Significant at P < 0.01.
4
Significant at P < 0.001.