Table 2.
Transcriptomic Analysis of TSG-6–/– Epidermis through RNA Sequencing
| TSG-6–/– (a) |
TSG-6–/– (b) |
||||
|---|---|---|---|---|---|
| ID | Gene | log2FC | Padj | log2FC | Padj |
| ENSG00000123610 | TNFAIP6 | –7.41503 | 2.96E–32 | –7.32736 | 3E–30 |
| ENSG00000234444 | ZNF736 | –4.44636 | 2.81E–22 | –4.69333 | 3.14E–18 |
| ENSG00000170430 | MGMT | –4.33712 | 8.06E–16 | –4.18849 | 3.18E–12 |
| ENSG00000105750 | ZNF85 | –3.87594 | 3.01E–37 | –2.40597 | 9.47E–27 |
| ENSG00000144115 | THNSL2 | –3.86052 | 2.91E–15 | –3.78559 | 1.02E–13 |
| ENSG00000187210 | GCNT1 | –3.0438 | 6E–50 | –2.61444 | 6.09E–38 |
| ENSG00000011465 | DCN | –2.82165 | 1.1E–84 | –1.5491 | 3.33E–29 |
| ENSG00000188257 | PLA2G2A | –2.7461 | 1.93E–24 | –2.00917 | 1.94E–14 |
| ENSG00000177990 | DPY19L2 | –2.37162 | 3.21E–10 | –2.42415 | 6.58E–09 |
| ENSG00000153802 | TMPRSS11D | –2.35278 | 9.53E–15 | –1.24544 | 0.00015 |
| ENSG00000129455 | KLK8 | –2.27628 | 3.22E–18 | –1.70997 | 1.05E–10 |
| ENSG00000122691 | TWIST1 | –2.26396 | 2.75E–06 | –2.35514 | 8.97E–08 |
| ENSG00000103546 | SLC6A2 | –2.23051 | 1.73E–11 | –1.01528 | 0.002253 |
| ENSG00000102837 | OLFM4 | –2.10858 | 1.07E–09 | –2.29476 | 3.6E–09 |
| ENSG00000188868 | ZNF563 | –2.01096 | 1.75E–17 | –2.394 | 7.67E–21 |
| ENSG00000244242 | IFITM10 | –1.93999 | 6.41E–12 | –1.9349 | 1.62E–10 |
| ENSG00000153292 | ADGRF1 | –1.93659 | 6.88E–08 | –1.08517 | 0.008469 |
| ENSG00000206195 | DUXAP8 | –1.88083 | 3.76E–05 | –2.0841 | 6.63E–07 |
| ENSG00000213096 | ZNF254 | –1.8603 | 1.41E–38 | –1.78 | 1.78E–33 |
| ENSG00000260027 | HOXB7 | –1.72059 | 2.43E–05 | –2.21449 | 1.82E–05 |
| ENSG00000081803 | CADPS2 | –1.64989 | 2.05E–05 | –1.67567 | 1.61E–05 |
| ENSG00000237440 | AC008554.1 | –1.61936 | 0.000136 | –2.20067 | 5.76E–08 |
| ENSG00000105357 | MYH14 | –1.48954 | 1.63E–16 | –1.0035 | 3.51E–07 |
| ENSG00000101017 | CD40 | –1.47799 | 5.85E–06 | –2.08413 | 1.64E–08 |
| ENSG00000172478 | MAB21L4 | –1.44783 | 9.05E–36 | –1.82477 | 1.8E–52 |
| ENSG00000197647 | ZNF433 | –1.36208 | 5.15E–08 | –2.48496 | 3.31E–17 |
| ENSG00000167754 | KLK5 | –1.34785 | 2.03E–16 | –1.92299 | 1.2E–30 |
| ENSG00000198182 | ZNF607 | –1.344 | 3.92E–17 | –1.09462 | 7.89E–11 |
| ENSG00000250644 | AC068580.4 | –1.33136 | 8.21E–07 | –1.14364 | 0.000121 |
| ENSG00000160284 | SPATC1L | –1.27579 | 0.001851 | –1.65145 | 0.000263 |
| ENSG00000196263 | ZNF471 | –1.20779 | 9.05E–05 | –1.20674 | 0.000435 |
| ENSG00000077063 | CTTNBP2 | –1.16597 | 7.2E–06 | –2.10572 | 5.59E–12 |
| ENSG00000235584 | AC008268.1 | –1.15826 | 2.67E–07 | –1.34538 | 1.76E–08 |
| ENSG00000091656 | ZFHX4 | –1.14386 | 0.00455 | –1.27665 | 0.005149 |
| ENSG00000196172 | ZNF681 | –1.13207 | 3.24E–16 | –1.08222 | 1.35E–13 |
| ENSG00000150687 | PRSS23 | –1.04503 | 8.83E–14 | –1.57255 | 8.84E–28 |
| ENSG00000139445 | FOXN4 | –1.03112 | 0.000567 | –1.48352 | 3.45E–06 |
| ENSG00000219665 | ZNF433-AS1 | –1.0184 | 0.003964 | –1.37053 | 0.000331 |
| ENSG00000130038 | CRACR2A | 4.155504 | 4.42E–37 | 1.339632 | 3.03E–05 |
| ENSG00000007038 | PRSS21 | 2.825615 | 4.82E–27 | 1.229979 | 3.46E–05 |
| ENSG00000248370 | LINC02434 | 2.61115 | 6.57E–43 | 1.637452 | 8.7E–16 |
| ENSG00000150722 | PPP1R1C | 2.394706 | 1.72E–10 | 1.089967 | 0.003993 |
| ENSG00000182389 | CACNB4 | 2.179791 | 1.85E–23 | 1.175044 | 1.83E–06 |
| ENSG00000131771 | PPP1R1B | 2.1777 | 1.76E–11 | 1.057933 | 0.004363 |
| ENSG00000141753 | IGFBP4 | 2.083609 | 1.45E–42 | 1.219661 | 3.22E–13 |
| ENSG00000108176 | DNAJC12 | 2.057347 | 2.89E–15 | 1.800988 | 4.46E–11 |
| ENSG00000234929 | AC018685.2 | 1.77764 | 1.76E–10 | 1.325183 | 1.51E–05 |
| ENSG00000166897 | ELFN2 | 1.660626 | 3.69E–06 | 1.268515 | 0.000785 |
| ENSG00000153064 | BANK1 | 1.481794 | 5.99E–08 | 1.306159 | 1.21E–05 |
| ENSG00000100968 | NFATC4 | 1.471711 | 2.94E–11 | 1.093399 | 9.51E–06 |
| ENSG00000251003 | ZFPM2-AS1 | 1.354186 | 3.59E–20 | 1.06091 | 2.67E–11 |
| ENSG00000131634 | TMEM204 | 1.305841 | 1.52E–10 | 2.388995 | 4.19E–33 |
| ENSG00000164684 | ZNF704 | 1.215393 | 4.55E–09 | 1.085985 | 1.47E–06 |
| ENSG00000141622 | RNF165 | 1.162247 | 7.5E–05 | 1.046022 | 0.001585 |
| ENSG00000179914 | ITLN1 | 1.144014 | 0.000195 | 1.104532 | 0.001204 |
| ENSG00000279108 | AC008537.3 | 1.114701 | 0.001084 | 1.41162 | 0.000283 |
| ENSG00000225968 | ELFN1 | 1.04966 | 0.002312 | 1.356617 | 0.000548 |
| ENSG00000172005 | MAL | 1.00604 | 0.000887 | 1.881428 | 3.6E–10 |
Abbreviations: Padj, adjusted P; FC, fold change; RHE, reconstructed human epidermis.
List of commonly downregulated and upregulated genes in both IL-4‒ and IL-13‒challenged TSG-6–/– RHE compared with challenged TSG-6+/+ RHE (FC ≥ 2; P < 0.01).