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. 2021 May 6;1(2):100020. doi: 10.1016/j.xjidi.2021.100020

Figure 2.

Figure 2

Effect of dHACM on TGFβ1-induced fibrotic response in HDFs. Fold change in gene expression of fibrosis markers (a) PAI-1 and (b) CTGF and ECM components (c) COL1A1, (d) COL3A1, (e) FN1, and (f) ELN in HDFs after 24-hour stimulation with TGFβ1 and 24-hour treatment with dHACM + TGFβ1. Values are normalized relative to those of 18S endogenous control for each experiment. All values represent mean ± SD. ∗P < 0.05 versus TGFβ1 group and #P < 0.05 versus basal group using one-way ANOVA; n = 3 dHACM donors. dHACM, dehydrated human amnion/chorion membrane; ECM, extracellular matrix; ELN, elastin; FN, fibronectin; HDF, human dermal fibroblast.