Table 1.
Th2/17 and ILC2/3 Cell Percentages and Clinical Information about Each Patient
| % Total CD4 T Cells | Absolute Numbers (/μl) | % Change from Baseline | % Total ILCs | Absolute Numbers (/μl) | % Change from Baseline | |||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
Timepoint (Weeks) |
AD Patient ID | Gender | Age | IGA | EASI | % Change in EASI from Baseline | Th2 | Th1 | Th17 | Th2/17 ratio | Th2 | Th1 | Th17 | Th2 | Th1 | Th17 | ILC2 | ILC1 | ILC3 | ILC2/3 ratio | ILC2 | ILC1 | ILC3 | ILC2 | ILC1 | ILC3 | TARC (pg/ml) | Total IgE (IU/ml) |
| 0 | 924 | M | 48 | 3 | 39.6 | −89.4 | 12.0 | 12.7 | 9.8 | 1.23 | 213 | 226 | 173 | 20.8 | −20.5 | 63.1 | 29.5 | 50.0 | 20.5 | 1.44 | 0.88 | 1.50 | 0.61 | −42.9 | −27.3 | 128.6 | 11,680 | 27,100 |
| 16 | 1 | 4.2 | 14.5 | 10.1 | 15.9 | 0.91 | 188 | 131 | 206 | 16.9 | 36.4 | 46.8 | 0.36 | 0.62 | 1.33 | 1.71 | 779 | 11,100 | ||||||||||
| 0 | 929 | M | 38 | 4 | 46.6 | −100.0 | 15.7 | 11.2 | 11.5 | 1.37 | 270 | 193 | 198 | −24.8 | −44.8 | −7.0 | 25.0 | 50.0 | 25.0 | 1.00 | 1.18 | 2.36 | 1.18 | −37.3 | −31.7 | 100.8 | 950 | 3460 |
| 16 | 0 | 0 | 11.8 | 6.2 | 10.7 | 1.10 | 161 | 84 | 146 | 15.7 | 34.1 | 50.2 | 0.31 | 0.73 | 1.58 | 2.33 | 161 | 697 | ||||||||||
| 0 | 934 | M | 28 | 4 | 52.4 | −93.5 | 19.7 | 25.4 | 6.2 | 3.16 | 207 | 267 | 65 | −46.2 | 3.1 | 7.1 | 68.1 | 27.8 | 4.1 | 16.46 | 15.07 | 6.14 | 0.92 | −37.9 | 52.3 | 272.8 | 10,510 | 2,060 |
| 16 | 1 | 3.4 | 10.6 | 26.2 | 6.7 | 1.59 | 75 | 186 | 47 | 42.3 | 42.3 | 15.4 | 2.74 | 4.00 | 4.00 | 1.46 | 256 | 1,230 | ||||||||||
| 0 | 902 | M | 23 | 4 | 46.5 | −92.7 | 10.7 | 7.3 | 3.6 | 2.98 | 166 | 112 | 56 | 26.2 | −82.3 | 67.4 | 52.9 | 39.9 | 7.2 | 7.36 | 6.22 | 4.68 | 0.84 | 3.4 | −19.5 | 83.7 | 5,777 | 29,300 |
| 16 | 2 | 3.4 | 13.5 | 1.3 | 6.0 | 2.25 | 126 | 12 | 56 | 54.7 | 32.1 | 13.2 | 4.14 | 6.68 | 3.92 | 1.61 | 329 | 10,300 | ||||||||||
| 0 | 909 | F | 60 | 4 | 52.2 | −94.6 | 16.9 | 7.1 | 5.7 | 2.95 | 132 | 55 | 45 | −3.0 | −6.2 | 78.3 | 21.7 | 62.0 | 16.3 | 1.33 | 0.42 | 1.20 | 0.32 | −53.4 | −26.2 | 171.0 | 19,140 | 1,480 |
| 16 | 1 | 2.8 | 16.4 | 6.6 | 10.2 | 1.61 | 118 | 48 | 73 | 10.1 | 45.7 | 44.2 | 0.23 | 0.30 | 1.35 | 1.30 | 489 | 889 | ||||||||||
| 0 | 923 | M | 49 | 4 | 42.9 | −71.3 | 15.0 | 21.1 | 19.5 | 0.77 | 140 | 197 | 182 | −14.7 | −64.5 | −22.6 | 21.6 | 55.4 | 23.0 | 0.94 | 0.92 | 2.37 | 0.98 | −13.3 | −5.2 | 25.1 | 1,459 | 1,000 |
| 16 | 2 | 12.3 | 12.8 | 7.5 | 15.1 | 0.85 | 81 | 47 | 96 | 18.8 | 52.5 | 28.8 | 0.65 | 0.75 | 2.10 | 1.15 | 587 | 383 | ||||||||||
| 0 | 930 | M | 52 | 4 | 22.7 | −78.4 | 24.8 | 15.7 | 14.2 | 1.75 | 315 | 199 | 180 | −9.3 | −47.8 | −48.2 | 5.7 | 85.0 | 9.3 | 0.62 | 0.72 | 10.74 | 1.17 | −17.2 | −1.7 | 26.2 | 4,760 | 35,800 |
| 16 | 1 | 4.9 | 22.5 | 8.2 | 7.4 | 3.06 | 169 | 62 | 55 | 4.7 | 83.6 | 11.7 | 0.40 | 0.93 | 16.47 | 2.31 | 467 | 12,000 | ||||||||||
| 0 | 938 | M | 42 | 3 | 26.7 | −84.6 | 13.1 | 11.6 | 14.9 | 0.88 | 145 | 128 | 165 | −38.2 | −26.4 | −51.0 | 14.8 | 69.3 | 15.9 | 0.93 | 0.85 | 4.00 | 0.92 | −4.4 | 6.9 | −26.1 | 696 | 6,380 |
| 16 | 2 | 4.1 | 8.1 | 8.5 | 7.3 | 1.11 | 93 | 99 | 84 | 14.1 | 74.1 | 11.8 | 1.20 | 0.65 | 3.42 | 0.54 | 343 | 3,340 | ||||||||||
| 0 | 895 | M | 23 | 3 | 17.4 | −88.5 | 21.9 | 10.3 | 21.1 | 1.04 | 218 | 102 | 210 | −6.4 | 8.7 | −10.9 | 18.0 | 59.5 | 22.5 | 0.80 | 0.93 | 3.08 | 1.17 | −7.5 | −23.9 | 69.1 | 755 | 1,350 |
| 16 | 1 | 2 | 20.5 | 11.2 | 18.8 | 1.09 | 58 | 32 | 54 | 16.7 | 45.2 | 38.1 | 0.44 | 1.07 | 2.90 | 2.44 | 315 | 606 | ||||||||||
| 0 | 900 | M | 29 | 3 | 27.3 | −80.6 | No data | 66.7 | 23.4 | 9.9 | 6.73 | 2.48 | 0.87 | 0.37 | −34.2 | 27.3 | 165.6 | 526 | 13,500 | |||||||||
| 16 | 0 | 5.3 | 43.9 | 29.8 | 26.3 | 1.67 | 1.95 | 1.33 | 1.17 | 195 | 4,840 | |||||||||||||||||
| 0 | 918 | M | 38 | 3 | 37 | −79.5 | 19.2 | 8.0 | 18.7 | 1.03 | 271 | 113 | 263 | −13.0 | −24.4 | −3.7 | 49.0 | 39.5 | 11.5 | 4.26 | 2.99 | 2.41 | 0.70 | −38.8 | −1.9 | 171.6 | 4,459 | 7,760 |
| 16 | 2 | 7.6 | 16.7 | 6.1 | 18.0 | 0.93 | 151 | 55 | 162 | 30.0 | 38.8 | 31.3 | 0.96 | 1.53 | 1.98 | 1.60 | 410 | 4,120 | ||||||||||
| 0 | 926 | M | 57 | 4 | 54.6 | −85.7 | 20.5 | 13.2 | 18.0 | 1.14 | 279 | 179 | 245 | −6.8 | −37.6 | −31.7 | 7.0 | 41.9 | 51.1 | 0.14 | 0.20 | 1.19 | 1.45 | −51.9 | 0.4 | 6.8 | 419 | 5,180 |
| 16 | 2 | 7.8 | 19.1 | 8.2 | 12.3 | 1.55 | 179 | 77 | 115 | 3.4 | 42.1 | 54.5 | 0.06 | 0.08 | 0.99 | 1.28 | 865 | 3,520 | ||||||||||
| 0 | 932 | M | 42 | 4 | 66 | −79.4 | No data | 12.4 | 77.5 | 10.1 | 1.23 | 0.37 | 2.31 | 0.30 | −12.7 | −12.9 | 115.0 | 8,066 | 110,000 | |||||||||
| 16 | 2 | 13.6 | 10.8 | 67.5 | 21.7 | 0.50 | 0.36 | 2.25 | 0.72 | 681 | 54,600 | |||||||||||||||||
| 0 | 939 | M | 49 | 4 | 57.6 | −62.8 | 32.5 | 5.9 | 16.6 | 1.96 | 870 | 157 | 444 | −12.3 | 24.1 | −7.2 | 20.1 | 69.6 | 10.3 | 1.96 | 6.61 | 22.84 | 3.37 | −5.3 | −10.0 | 78.0 | 4,380 | 9,200 |
| 16 | 3 | 21.4 | 28.5 | 7.3 | 15.4 | 1.85 | 313 | 80 | 169 | 19.1 | 62.7 | 18.3 | 1.04 | 5.66 | 18.61 | 5.42 | 341 | 2,920 | ||||||||||
| 0 | 942 | M | 25 | 4 | 40.4 | −80.0 | 16.8 | 8.6 | 6.3 | 2.68 | 165 | 84 | 62 | −26.2 | 12.4 | 14.0 | 36.5 | 24.0 | 39.6 | 0.92 | 2.59 | 1.70 | 2.82 | −56.8 | 87.2 | −0.5 | 2,154 | 29.3 |
| 16 | 1 | 8.1 | 12.4 | 9.6 | 7.2 | 1.73 | 136 | 106 | 79 | 15.8 | 44.8 | 39.4 | 0.40 | 1.39 | 3.94 | 3.46 | 308 | 10.3 | ||||||||||
| 0 | 947 | M | 42 | 3 | 11.3 | −90.3 | 11.2 | 15.6 | 12.3 | 0.91 | 207 | 288 | 227 | −8.0 | 46.2 | 9.8 | 43.4 | 12.1 | 44.4 | 0.98 | 3.18 | 0.89 | 3.25 | −23.3 | 16.3 | 18.3 | 414 | 1,430 |
| 16 | 1 | 1.1 | 10.3 | 22.8 | 13.5 | 0.76 | 106 | 234 | 138 | 33.3 | 14.1 | 52.6 | 0.63 | 1.35 | 0.57 | 2.12 | 122 | 830 | ||||||||||
| 0 | 954 | M | 30 | 3 | 38 | −63.7 | 6.5 | 4.2 | 5.4 | 1.22 | 51 | 33 | 42 | 47.8 | −19.7 | 37.6 | 20.0 | 28.0 | 52.0 | 0.38 | 0.31 | 0.43 | 0.80 | 0.0 | −28.6 | 15.4 | 4,634 | 9,020 |
| 16 | 3 | 13.8 | 9.7 | 3.4 | 7.4 | 1.31 | 77 | 27 | 59 | 20.0 | 20.0 | 60.0 | 0.33 | 0.44 | 0.44 | 1.32 | 373 | 4,890 | ||||||||||
| 0 | 953 | F | 52 | 4 | 52.4 | −56.1 | 15.4 | 31.0 | 18.4 | 0.84 | 65 | 131 | 78 | 3.2 | −53.2 | 2.2 | 28.6 | 14.3 | 57.1 | 0.50 | 0.18 | 0.09 | 0.37 | −1.6 | 118.8 | −28.9 | 2,078 | 5,070 |
| 16 | 2 | 23 | 15.9 | 14.5 | 18.8 | 0.85 | 70 | 63 | 82 | 28.1 | 31.3 | 40.6 | 0.69 | 0.47 | 0.52 | 0.67 | 370 | 1,770 | ||||||||||
| 0 | 994 | M | 44 | 4 | 48.8 | −65.4 | 16.4 | 1.4 | 4.2 | 3.87 | 185 | 15 | 48 | −14.0 | 572.6 | 101.2 | 25.0 | 25.0 | 50.0 | 0.50 | 0.22 | 0.22 | 0.44 | −51.5 | 33.3 | 9.1 | 988 | 2,310 |
| 16 | 2 | 16.9 | 14.1 | 9.1 | 8.5 | 1.65 | 168 | 108 | 102 | 12.1 | 33.3 | 54.5 | 0.22 | 0.26 | 0.71 | 1.16 | 920 | 774 | ||||||||||
| 0 | 965 | M | 41 | 4 | 56.1 | −77.0 | 38.7 | 7.1 | 23.7 | 1.63 | 236 | 43 | 145 | −32.8 | −59.7 | −45.1 | 26.8 | 58.5 | 14.6 | 1.83 | 0.91 | 1.98 | 0.49 | −9.6 | −48.2 | 210.6 | 22,660 | 29,500 |
| 16 | 2 | 12.9 | 26.0 | 2.9 | 13.0 | 2.00 | 144 | 16 | 72 | 24.2 | 30.3 | 45.5 | 0.53 | 0.51 | 0.64 | 0.96 | 224 | 11,600 | ||||||||||
| 0 | 1021 | M | 38 | 3 | 47.2 | −41.9 | 15.3 | 5.0 | 9.8 | 1.56 | 154 | 50 | 99 | 8.5 | 25.9 | 38.5 | 16.7 | 22.2 | 61.1 | 0.27 | 0.16 | 0.22 | 0.60 | −10.0 | −21.2 | 10.5 | 5,196 | 7,230 |
| 16 | 3 | 27.4 | 16.6 | 6.3 | 13.6 | 1.22 | 214 | 81 | 176 | 15.0 | 17.5 | 67.5 | 0.22 | 0.33 | 0.39 | 1.49 | 566 | 3,000 | ||||||||||
| 0 | 980 | M | 43 | 4 | 34.8 | −58.3 | 4.7 | 16.3 | 4.6 | 1.03 | 45 | 153 | 43 | −0.2 | −87.9 | −41.8 | 13.6 | 59.1 | 27.3 | 0.50 | 0.19 | 0.81 | 0.37 | 4.8 | −23.4 | 48.4 | 1,756 | 5,160 |
| 16 | 2 | 14.5 | 4.7 | 2.0 | 2.7 | 1.77 | 67 | 20 | 27 | 14.3 | 45.2 | 40.5 | 0.35 | 0.38 | 1.22 | 1.09 | 100 | 1,820 | ||||||||||
| 0 | 1002 | M | 43 | 3 | 18.2 | −85.7 | 9.8 | 2.3 | 6.4 | 1.54 | 41 | 26 | 70 | −3.2 | 100.9 | −2.5 | 39.1 | 26.1 | 34.8 | 1.13 | 0.48 | 0.32 | 0.43 | −27.0 | 9.5 | 23.2 | 2,217 | 9,750 |
| 16 | 2 | 2.6 | 9.5 | 4.7 | 6.2 | 1.53 | 115 | 30 | 39 | 28.6 | 28.6 | 42.9 | 0.67 | 0.46 | 0.46 | 0.69 | 738 | 6,680 | ||||||||||
| 0 | 1049 | M | 34 | 3 | 21.3 | −53.1 | 19.3 | 6.2 | 7.7 | 2.51 | 148 | 48 | 59 | 1.0 | 160.0 | 19.1 | 20.0 | 42.5 | 37.5 | 0.53 | 0.44 | 0.95 | 0.83 | 45.8 | −41.2 | 22.2 | 2,756 | 5,730 |
| 16 | 2 | 10 | 19.5 | 16.2 | 9.2 | 2.13 | 112 | 93 | 53 | 29.2 | 25.0 | 45.8 | 0.64 | 0.40 | 0.34 | 0.63 | 257 | 2,590 | ||||||||||
| 0 | 1062 | F | 29 | 3 | 24.5 | −75.5 | 8.3 | 11.6 | 9.0 | 0.92 | 147 | 205 | 159 | 4.3 | 50.9 | 56.3 | 23.1 | 33.1 | 43.8 | 0.53 | 2.24 | 3.20 | 4.25 | −60.2 | 22.3 | 15.0 | 316 | 32.9 |
| 16 | 2 | 6 | 8.7 | 17.5 | 14.1 | 0.62 | 119 | 239 | 193 | 9.2 | 40.4 | 50.4 | 0.18 | 0.91 | 3.98 | 4.96 | 101 | 6 | ||||||||||
| 0 | 945 | M | 46 | 3 | 22.4 | −51.8 | 10.5 | 14.0 | 5.8 | 1.83 | 147 | 195 | 80 | 1.9 | −12.1 | 89.6 | 26.7 | 35.0 | 38.3 | 0.70 | 0.86 | 1.13 | 1.23 | −10.7 | −25.2 | 30.4 | 1,513 | 8,710 |
| 16 | 1 | 10.8 | 10.7 | 12.3 | 10.9 | 0.98 | 140 | 161 | 143 | 23.8 | 26.2 | 50.0 | 0.48 | 0.83 | 0.91 | 1.74 | 346 | 4,930 | ||||||||||
| 0 | 1058 | M | 28 | 3 | 22.4 | −78.6 | 15.7 | 4.8 | 9.5 | 1.66 | 194 | 59 | 117 | −39.9 | 241.0 | 2.6 | 26.0 | 22.0 | 52.0 | 0.50 | 0.73 | 0.62 | 1.46 | −29.0 | −23.1 | 24.3 | 2,561 | 757 |
| 16 | 1 | 4.8 | 9.4 | 16.3 | 9.7 | 0.97 | 112 | 194 | 116 | 18.5 | 16.9 | 64.6 | 0.29 | 0.64 | 0.59 | 2.26 | 318 | 191 | ||||||||||
Abbreviations: AD, atopic dermatitis; EASI, Eczema Area and Severity Index; F, Female; ID, identification; IGA, Investigator Global Assessment; ILC, innate lymphoid cell; M, male; Th, T helper type.