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. 2021 Nov 15;10:e73753. doi: 10.7554/eLife.73753

Figure 2. Water extract of Gastrodia elata Blume (WGE) prevents loss of dopaminergic neurons in Ddc>G2019S flies.

(A) Representative adult brain images showing TH-positive dopaminergic neurons in the PPL1 cluster of 2-, 4-, and 6-week-old flies of the Ddc>Lrrk2, Ddc>G2019S, and 0.1% WGE-fed Ddc>G2019S groups. Scale bar: 10 μm. (B) Average numbers (mean ± SEM, N = 5) of TH-positive dopaminergic neurons in the PPL1, PPM1/2, PPL2, and PPL3 clusters per brain hemisphere. One-way ANOVA with Tukey’s post-hoc multiple comparison test: *p<0.05, **p<0.01, ***p<0.001, ns, not significant.

Figure 2.

Figure 2—figure supplement 1. Water extract of Gastrodia elata Blume (WGE) treatment prevents dopaminergic neuron loss in Ddc>G2019S flies.

Figure 2—figure supplement 1.

(A–C) Representative adult whole-brain images for TH staining to reveal dopaminergic neurons in the PPL1, PPL2, PPM1/2, and PPM3 clusters of 2-, 4-, and 6-week-old flies. Scale bar: 40 μm. The images for the PPL1 cluster are shown as enhanced views of the dashed boxes in Figure 2.