Figure 5.
Reduced APP processing before stretch abrogates stretch-induced formation of APP axonal accumulations. A, Representative images and quantitative analysis of APP-YFP axonal transport 24 h after stretch, in axons exposed to CE (5 μm) or vehicle (DMSO 0.01%) during 1 h before being stretched (*p = 0.0251 for anterograde and *p = 0.0491 for density, both compared with DMSO) (n = 9 or more). B, Quantitative analysis of APPMV-YFP puncta movement and density 24 h after stretch (n = 5). Arrows indicate accumulated puncta along stretched axons in A. Data are mean ± SEM; means were compared by unpaired Student's t test. Scale bars: A, 10 μm.