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Schematic illustration showing the influence of GlcN in myelopoiesis and MDSC functions. GlcN interferes myelopoiesis by downregulating the gene expression of critical transcription factors and cytokines involved in HSPC differentiation and myelopoiesis to produce more immature myeloid cells, MDSCs. In addition, GlcN increases STAT3 and ERK1/2 phosphorylation to enhance the MDSC immunosuppressive ability.
